Effects of group housing on ECG assessment in conscious cynomolgus monkeys

Assessing the cardiovascular safety of new chemical or biological entities is important during pre-clinical development. Electrocardiogram (ECG) assessments in non-human primate (NHP) toxicology studies are often made using non-invasive telemetry systems. We investigated whether ECG recording was fe...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2015-09, Vol.75, p.44-51
Hauptverfasser:	Xing, Guozhen, Lu, Jing, Hu, Miaomiao, Wang, Shaodong, Zhao, Li, Zheng, Weijun, Schofield, Jason, Oldman, Karen, Adkins, Debbie, Yu, Hong, Platz, Stefan, Ren, Jin, Skinner, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Electrocardiogram Electrocardiography - methods Female Fluoroquinolones - administration & dosage Fluoroquinolones - toxicity Group housing Heart rate Heart Rate - drug effects Heart Rate - physiology Housing, Animal Long QT Syndrome - chemically induced Long QT Syndrome - diagnosis Macaca fascicularis Male Methods Moxifloxacin Non-human primate Non-invasive telemetry QT interval Safety pharmacology Single housing Telemetry - methods Toxicity Tests - methods
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