Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome

Background:Brugada syndrome (BrS) is an inheritable cardiac disease associated with syncope, malignant ventricular arrhythmias and sudden cardiac death. The largest proportion of mutations in BrS is found in theSCN5Agene encoding the α-subunit of cardiac sodium channels (Nav1.5). CausalSCN5Amutation...

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Veröffentlicht in:	Circulation Journal 2015/09/25, Vol.79(10), pp.2118-2129
Hauptverfasser:	Peeters, Uschi, Scornik, Fabiana, Riuró, Helena, Pérez, Guillermo, Komurcu-Bayrak, Evrim, Malderen, Sophie Van, Pappaert, Gudrun, Tarradas, Anna, Pagans, Sara, Daneels, Dorien, Breckpot, Karine, Brugada, Pedro, Bonduelle, Maryse, Brugada, Ramon, Dooren, Sonia Van
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Brugada syndrome Brugada Syndrome - genetics Brugada Syndrome - mortality Brugada Syndrome - physiopathology Female Functional studies HEK293 Cells Humans Male Middle Aged Mutation NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Patch clamp SCN1-4B Voltage-Gated Sodium Channel beta Subunits - genetics Voltage-Gated Sodium Channel beta Subunits - metabolism
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