Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia
The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data...
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| Veröffentlicht in: | Chinese journal of natural medicines 2015-09, Vol.13 (9), p.704-706 |
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| creator | GENG, Di YI, Li-Tao SHI, Yao MIN, Zhi-Da |
| description | The present study was designed to isolate and evaluate the antibacterial activity of the compounds from the whole plant of Euphorbia helioscopia L.. Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data（^1H NMR, ^13 C NMR, ^1H-^1H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS）. A new jatrophone-type diterpenoid（14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene）, named euphoheliosnoid E（1）, was isolated from the whole plant of E. helioscopia L. Compound 1 showed significant anti-microbial activity against oral pathogens. |
| doi_str_mv | 10.1016/S1875-5364(15)30069-8 |
| format | Article |
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Various chromatographic techniques were used to isolate and purify the compound. The structure of the compound was elucidated on basis of spectral data（^1H NMR, ^13 C NMR, ^1H-^1H COSY, HSQC, HMBC, NOESY, IR, and HR-ESI-MS）. A new jatrophone-type diterpenoid（14α,15β-diacetoxy-3β-benzoyloxy-7β-nicotinoyloxy-9-oxo-jatropha-5E,11E-diene）, named euphoheliosnoid E（1）, was isolated from the whole plant of E. helioscopia L. 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| subjects | Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Anti-microbial activity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Euphoheliosnoid E Euphorbia - chemistry Euphorbia helioscopia Jatrophone-type diterpenoid Molecular Structure Mouth Diseases - microbiology Niacin - analogs & derivatives Niacin - chemistry Niacin - isolation & purification Niacin - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology 剂型 药剂学 药学 调剂学 |
| title | Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia |
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