Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma
The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013...
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| Veröffentlicht in: | Genetics and molecular research 2015-09, Vol.14 (3), p.10524-10529 |
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| creator | Zhang, H F Yan, J P Zhuang, Y S Han, G Q |
| description | The aim of this study was to assess the role of the VEGF -2578C/A, +936C/T, and -460T/C gene polymorphisms in the development of osteosarcoma. A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not. By conditional regression analysis, we detected a statistically significantly increased risk of osteosarcoma in patients with the AA genotype (OR = 1.97; 95%CI = 1.02-3.83) and the CA+AA genotype (OR = 1.57; 95%CI = 1.01-2.44) of -2578C/A when compared with CC genotype. Therefore, our study showed that the AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population. |
| doi_str_mv | 10.4238/2015.September.8.14 |
| format | Article |
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A total of 182 patients with osteosarcoma and 182 age- and gender-matched healthy controls were enrolled into our study during January 2011 and December 2013. Genotype frequencies of the VEGF -2578C/A and -460T/C alleles in controls were found to be within the parameters of Hardy-Weinberg equilibrium, but the genotype frequencies of +936C/T alleles were not. By conditional regression analysis, we detected a statistically significantly increased risk of osteosarcoma in patients with the AA genotype (OR = 1.97; 95%CI = 1.02-3.83) and the CA+AA genotype (OR = 1.57; 95%CI = 1.01-2.44) of -2578C/A when compared with CC genotype. 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| subjects | Adolescent Adult Alleles Asian Continental Ancestry Group Bone Neoplasms - ethnology Bone Neoplasms - genetics Bone Neoplasms - pathology Case-Control Studies Child Female Gene Expression Gene Frequency Genetic Predisposition to Disease Genotype Humans Male Odds Ratio Osteosarcoma - ethnology Osteosarcoma - genetics Osteosarcoma - pathology Polymorphism, Single Nucleotide Regression Analysis Risk Vascular Endothelial Growth Factor A - genetics |
| title | Association between angiogenic growth factor genetic polymorphisms and the risk of osteosarcoma |
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