Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats

ABSTRACT Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread muscul...

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Veröffentlicht in:	Physiology & behavior 2015-11, Vol.151, p.456-462
Hauptverfasser:	Blasco-Serra, Arantxa, Escrihuela-Vidal, Francesc, González-Soler, Eva M, Martínez-Expósito, Fernando, Blasco-Ausina, Mª Carmen, Martínez-Bellver, Sergio, Cervera-Ferri, Ana, Teruel-Martí, Vicent, Valverde-Navarro, Alfonso A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - toxicity Animal pain model Animals Depression Depression - etiology Disease Models, Animal Exploratory Behavior - drug effects Feeding Behavior - drug effects Fibromyalgia Fibromyalgia - chemically induced Fibromyalgia - complications Hindlimb Suspension Inhibition (Psychology) Male Motor Activity - drug effects Novelty-Suppressed Feeding Test Pain Threshold - drug effects Psychiatry Rats Rats, Sprague-Dawley Reserpine Reserpine - toxicity Time Factors
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