Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats
ABSTRACT Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread muscul...
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| Veröffentlicht in: | Physiology & behavior 2015-11, Vol.151, p.456-462 |
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| creator | Blasco-Serra, Arantxa Escrihuela-Vidal, Francesc González-Soler, Eva M Martínez-Expósito, Fernando Blasco-Ausina, Mª Carmen Martínez-Bellver, Sergio Cervera-Ferri, Ana Teruel-Martí, Vicent Valverde-Navarro, Alfonso A |
| description | ABSTRACT Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia. |
| doi_str_mv | 10.1016/j.physbeh.2015.07.033 |
| format | Article |
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A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2015.07.033</identifier><identifier>PMID: 26222614</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adrenergic Uptake Inhibitors - toxicity ; Animal pain model ; Animals ; Depression ; Depression - etiology ; Disease Models, Animal ; Exploratory Behavior - drug effects ; Feeding Behavior - drug effects ; Fibromyalgia ; Fibromyalgia - chemically induced ; Fibromyalgia - complications ; Hindlimb Suspension ; Inhibition (Psychology) ; Male ; Motor Activity - drug effects ; Novelty-Suppressed Feeding Test ; Pain Threshold - drug effects ; Psychiatry ; Rats ; Rats, Sprague-Dawley ; Reserpine ; Reserpine - toxicity ; Time Factors</subject><ispartof>Physiology & behavior, 2015-11, Vol.151, p.456-462</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-2716c4d68b73cc39a72dff2177014ca165de36ddbe778d80a818d9cbb6f2c4613</citedby><cites>FETCH-LOGICAL-c420t-2716c4d68b73cc39a72dff2177014ca165de36ddbe778d80a818d9cbb6f2c4613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938415300470$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26222614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blasco-Serra, Arantxa</creatorcontrib><creatorcontrib>Escrihuela-Vidal, Francesc</creatorcontrib><creatorcontrib>González-Soler, Eva M</creatorcontrib><creatorcontrib>Martínez-Expósito, Fernando</creatorcontrib><creatorcontrib>Blasco-Ausina, Mª Carmen</creatorcontrib><creatorcontrib>Martínez-Bellver, Sergio</creatorcontrib><creatorcontrib>Cervera-Ferri, Ana</creatorcontrib><creatorcontrib>Teruel-Martí, Vicent</creatorcontrib><creatorcontrib>Valverde-Navarro, Alfonso A</creatorcontrib><title>Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>ABSTRACT Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. These NSFT findings suggest the presence of depressive-like disorders in this animal model of fibromyalgia.</description><subject>Adrenergic Uptake Inhibitors - toxicity</subject><subject>Animal pain model</subject><subject>Animals</subject><subject>Depression</subject><subject>Depression - etiology</subject><subject>Disease Models, Animal</subject><subject>Exploratory Behavior - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - chemically induced</subject><subject>Fibromyalgia - complications</subject><subject>Hindlimb Suspension</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Novelty-Suppressed Feeding Test</subject><subject>Pain Threshold - drug effects</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reserpine</subject><subject>Reserpine - toxicity</subject><subject>Time Factors</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAQgC0EokvhJ4By5JIwfsTOXkCo5VGpqIeCxM1y7An1NomDnVTKv8fRLhy4dC5zmG9mNN8Q8ppCRYHKd4dqultTi3cVA1pXoCrg_AnZ0Ubxsgb18ynZAXBa7nkjzsiLlA6Qgwv-nJwxyRiTVOzIt0ucIqbkH7Ds_T0WaR2mOQyp8GNhilzCOPkRSz-6xaIrhuCwL0JXdL6NYVhN_8ubDY5mTi_Js870CV-d8jn58fnT94uv5fXNl6uLj9elFQzmkikqrXCyaRW3lu-NYq7rGFUKqLCGytohl861qFTjGjANbdzetq3smBWS8nPy9jh3iuH3gmnWg08W-96MGJakqaJKKAFCZbQ-ojaGlCJ2eop-MHHVFPRmUh_0yaTeTGpQOpvMfW9OK5Z2QPev66-6DHw4ApgPffAYdbIex-zIR7SzdsE_uuL9fxNs70dvTX-PK6ZDWOKYLWqqE9Ogb7d3bt-kNYd8GvA_PuCcig</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Blasco-Serra, Arantxa</creator><creator>Escrihuela-Vidal, Francesc</creator><creator>González-Soler, Eva M</creator><creator>Martínez-Expósito, Fernando</creator><creator>Blasco-Ausina, Mª Carmen</creator><creator>Martínez-Bellver, Sergio</creator><creator>Cervera-Ferri, Ana</creator><creator>Teruel-Martí, Vicent</creator><creator>Valverde-Navarro, Alfonso A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats</title><author>Blasco-Serra, Arantxa ; Escrihuela-Vidal, Francesc ; González-Soler, Eva M ; Martínez-Expósito, Fernando ; Blasco-Ausina, Mª Carmen ; Martínez-Bellver, Sergio ; Cervera-Ferri, Ana ; Teruel-Martí, Vicent ; Valverde-Navarro, Alfonso A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-2716c4d68b73cc39a72dff2177014ca165de36ddbe778d80a818d9cbb6f2c4613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adrenergic Uptake Inhibitors - toxicity</topic><topic>Animal pain model</topic><topic>Animals</topic><topic>Depression</topic><topic>Depression - etiology</topic><topic>Disease Models, Animal</topic><topic>Exploratory Behavior - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - chemically induced</topic><topic>Fibromyalgia - complications</topic><topic>Hindlimb Suspension</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Novelty-Suppressed Feeding Test</topic><topic>Pain Threshold - drug effects</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reserpine</topic><topic>Reserpine - toxicity</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blasco-Serra, Arantxa</creatorcontrib><creatorcontrib>Escrihuela-Vidal, Francesc</creatorcontrib><creatorcontrib>González-Soler, Eva M</creatorcontrib><creatorcontrib>Martínez-Expósito, Fernando</creatorcontrib><creatorcontrib>Blasco-Ausina, Mª Carmen</creatorcontrib><creatorcontrib>Martínez-Bellver, Sergio</creatorcontrib><creatorcontrib>Cervera-Ferri, Ana</creatorcontrib><creatorcontrib>Teruel-Martí, Vicent</creatorcontrib><creatorcontrib>Valverde-Navarro, Alfonso A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blasco-Serra, Arantxa</au><au>Escrihuela-Vidal, Francesc</au><au>González-Soler, Eva M</au><au>Martínez-Expósito, Fernando</au><au>Blasco-Ausina, Mª Carmen</au><au>Martínez-Bellver, Sergio</au><au>Cervera-Ferri, Ana</au><au>Teruel-Martí, Vicent</au><au>Valverde-Navarro, Alfonso A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>151</volume><spage>456</spage><epage>462</epage><pages>456-462</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>ABSTRACT Since the pathogenesis of fibromyalgia is unknown, treatment options are limited, ineffective and in fact based on symptom relief. A recently proposed rat model of fibromyalgia is based on central depletion of monamines caused by reserpine administration. This model showed widespread musculoskeletal pain and depressive-like symptoms, but the methodology used to measure such symptoms has been criticized. Evidence relates the high prevalence of pain and depression in fibromyalgia to common pathogenic pathways, most probably focused on the monoaminergic system. The present study aims at a validation of the reserpine model of fibromyalgia. For this purpose, rats undergoing this model have been tested for depressive-like symptoms with a Novelty-Suppressed Feeding Test adaptation. Animals administered with reserpine and subjected to forced food deprivation performed a smaller number of incursions to the center of the open field, evidenced by a decrease in the per-minute rate of the rats' approaching, smelling or touching the food. They also took more time to eat from the central food than control rats. 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| subjects | Adrenergic Uptake Inhibitors - toxicity Animal pain model Animals Depression Depression - etiology Disease Models, Animal Exploratory Behavior - drug effects Feeding Behavior - drug effects Fibromyalgia Fibromyalgia - chemically induced Fibromyalgia - complications Hindlimb Suspension Inhibition (Psychology) Male Motor Activity - drug effects Novelty-Suppressed Feeding Test Pain Threshold - drug effects Psychiatry Rats Rats, Sprague-Dawley Reserpine Reserpine - toxicity Time Factors |
| title | Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats |
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