Clipping or Extracting: Two Ways to Membrane Protein Degradation

Protein degradation is a fundamentally important process that allows cells to recognize and remove damaged protein species and to regulate protein abundance according to functional need. A fundamental challenge is to understand how membrane proteins are recognized and removed from cellular organelle...

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Veröffentlicht in:	Trends in cell biology 2015-10, Vol.25 (10), p.611-622
Hauptverfasser:	Avci, Dönem, Lemberg, Marius K
Format:	Artikel
Sprache:	eng
Schlagworte:	AAA-ATPase p97/VCP/Cdc48 Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Endoplasmic Reticulum - genetics Endoplasmic Reticulum-Associated Degradation - genetics endoplasmic reticulum-associated protein degradation Humans intramembrane proteolysis/protease Membrane Proteins - genetics Membrane Proteins - metabolism organellar protein homeostasis Pathology Proteasome Endopeptidase Complex Proteolysis Ubiquitin - genetics Valosin Containing Protein
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