Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait
Abstract Background Neuropsychological evaluation with advanced neuroimaging may be a useful tool to determine the anatomical substrates that play crucial role in freezing of gait (FOG) in patients with Parkinson's Disease (PD). Objectives To compare the cognitive profile and gray matter (GM) c...
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| Veröffentlicht in: | Parkinsonism & related disorders 2015-10, Vol.21 (10), p.1184-1190 |
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| creator | Jha, Menka Jhunjhunwala, Ketan Sankara, Bagepally B Saini, Jitender Kumar, J. Keshav Yadav, Ravi Pal, Pramod Kumar |
| description | Abstract Background Neuropsychological evaluation with advanced neuroimaging may be a useful tool to determine the anatomical substrates that play crucial role in freezing of gait (FOG) in patients with Parkinson's Disease (PD). Objectives To compare the cognitive profile and gray matter (GM) changes (using Voxel Based Morphometry – VBM) between patients with PD with and without FOG (FOG+ve and FOG−ve). Methods Seventeen FOG+ve (M:F = 11:6) and 21 FOG−ve (M:F = 11:10) were evaluated clinically and with a structured neuropsychological battery. All patients underwent 3 T MRI. In order to determine areas of GM atrophy, T1W volumetric MRI data of the two groups were compared using VBM and Statistical Parametric Mapping 8. Results The mean age of FOG+ve and FOG−ve patients were 56.9 ± 6.6 and 47.4 ± 9.1 years respectively. There was no significant difference in the duration (6.0 ± 4.9 vs 5.2 ± 3.5 years, p |
| doi_str_mv | 10.1016/j.parkreldis.2015.08.009 |
| format | Article |
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Keshav ; Yadav, Ravi ; Pal, Pramod Kumar</creator><creatorcontrib>Jha, Menka ; Jhunjhunwala, Ketan ; Sankara, Bagepally B ; Saini, Jitender ; Kumar, J. Keshav ; Yadav, Ravi ; Pal, Pramod Kumar</creatorcontrib><description>Abstract Background Neuropsychological evaluation with advanced neuroimaging may be a useful tool to determine the anatomical substrates that play crucial role in freezing of gait (FOG) in patients with Parkinson's Disease (PD). Objectives To compare the cognitive profile and gray matter (GM) changes (using Voxel Based Morphometry – VBM) between patients with PD with and without FOG (FOG+ve and FOG−ve). Methods Seventeen FOG+ve (M:F = 11:6) and 21 FOG−ve (M:F = 11:10) were evaluated clinically and with a structured neuropsychological battery. All patients underwent 3 T MRI. In order to determine areas of GM atrophy, T1W volumetric MRI data of the two groups were compared using VBM and Statistical Parametric Mapping 8. Results The mean age of FOG+ve and FOG−ve patients were 56.9 ± 6.6 and 47.4 ± 9.1 years respectively. There was no significant difference in the duration (6.0 ± 4.9 vs 5.2 ± 3.5 years, p < 0.05) and stage of PD (Hoehn & Yahr stage: 1.96 ± 0.53 vs 1.78 ± 0.37) between the two groups. Compared to the FOG−ve group, the FOG+ve group had (i) significant impairment in memory, attention, executive and visuospatial functions on neuropsychological tests, and (ii) significant GM atrophy in the right cerebellum (pyramis, declive), left cerebrum (Brodmann area (BA) 21 and 22) and right cerebrum (BA 10 and 6) on VBM analysis. Conclusions The FOG+ve group showed widespread involvement of cognition localizing to frontal, temporal (especially left) and parietal areas. VBM analysis showed significant GM atrophy in FOG+ve group in left temporal, right frontal areas (coinciding with that observed in neuropsychological tests) and significant involvement of right cerebellum.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2015.08.009</identifier><identifier>PMID: 26305999</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Atrophy ; Female ; Freezing of gait ; Gait ; Gait Disorders, Neurologic - etiology ; Gait Disorders, Neurologic - pathology ; Gait Disorders, Neurologic - psychology ; Gray Matter - pathology ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurology ; Neuropsychological assessment ; Neuropsychological Tests ; Parkinson Disease - complications ; Parkinson Disease - pathology ; Parkinson Disease - psychology ; Parkinson's disease ; Voxel based morphometry</subject><ispartof>Parkinsonism & related disorders, 2015-10, Vol.21 (10), p.1184-1190</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-3a082cb8f2488c0c4e989139ebe48673d52464db0ef370fa2d4ead2aa5b633463</citedby><cites>FETCH-LOGICAL-c429t-3a082cb8f2488c0c4e989139ebe48673d52464db0ef370fa2d4ead2aa5b633463</cites><orcidid>0000-0003-0856-767X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1353802015003417$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26305999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jha, Menka</creatorcontrib><creatorcontrib>Jhunjhunwala, Ketan</creatorcontrib><creatorcontrib>Sankara, Bagepally B</creatorcontrib><creatorcontrib>Saini, Jitender</creatorcontrib><creatorcontrib>Kumar, J. Keshav</creatorcontrib><creatorcontrib>Yadav, Ravi</creatorcontrib><creatorcontrib>Pal, Pramod Kumar</creatorcontrib><title>Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract Background Neuropsychological evaluation with advanced neuroimaging may be a useful tool to determine the anatomical substrates that play crucial role in freezing of gait (FOG) in patients with Parkinson's Disease (PD). Objectives To compare the cognitive profile and gray matter (GM) changes (using Voxel Based Morphometry – VBM) between patients with PD with and without FOG (FOG+ve and FOG−ve). Methods Seventeen FOG+ve (M:F = 11:6) and 21 FOG−ve (M:F = 11:10) were evaluated clinically and with a structured neuropsychological battery. All patients underwent 3 T MRI. In order to determine areas of GM atrophy, T1W volumetric MRI data of the two groups were compared using VBM and Statistical Parametric Mapping 8. Results The mean age of FOG+ve and FOG−ve patients were 56.9 ± 6.6 and 47.4 ± 9.1 years respectively. There was no significant difference in the duration (6.0 ± 4.9 vs 5.2 ± 3.5 years, p < 0.05) and stage of PD (Hoehn & Yahr stage: 1.96 ± 0.53 vs 1.78 ± 0.37) between the two groups. Compared to the FOG−ve group, the FOG+ve group had (i) significant impairment in memory, attention, executive and visuospatial functions on neuropsychological tests, and (ii) significant GM atrophy in the right cerebellum (pyramis, declive), left cerebrum (Brodmann area (BA) 21 and 22) and right cerebrum (BA 10 and 6) on VBM analysis. Conclusions The FOG+ve group showed widespread involvement of cognition localizing to frontal, temporal (especially left) and parietal areas. VBM analysis showed significant GM atrophy in FOG+ve group in left temporal, right frontal areas (coinciding with that observed in neuropsychological tests) and significant involvement of right cerebellum.</description><subject>Atrophy</subject><subject>Female</subject><subject>Freezing of gait</subject><subject>Gait</subject><subject>Gait Disorders, Neurologic - etiology</subject><subject>Gait Disorders, Neurologic - pathology</subject><subject>Gait Disorders, Neurologic - psychology</subject><subject>Gray Matter - pathology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological assessment</subject><subject>Neuropsychological Tests</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Voxel based morphometry</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1TAQhS0Eog_4C8g72CSMH4mdDRJUpSBVgASsjeNMbn2bGwc7obr8-jrcFiRWXdmLc2bOfIcQyqBkwOrX23Ky8Tri0PlUcmBVCboEaB6RY6aVKCrG68f5LypRaOBwRE5S2gKAqkA8JUe8FlA1TXNMfnzCJYYp7d1VGMLGOztQO3bU7-zGjxs6xdD7AWno6WRnj-Oc6I2fr-iXHMCPKYwvE80p0Cb8Y-wj4u_VmR0b6-dn5Elvh4TP795T8v39-bezD8Xl54uPZ28vCyd5MxfCguau1T2XWjtwEhvdMNFgi1LXSnQVl7XsWsBeKOgt7yTajltbtbUQshan5NVhbk78c8E0m51PDofBjhiWZJhiSireKJal-iB1MaQUsTdTzPfGvWFgVr5ma_7xNStfA9pkvtn64m7L0u6w-2u8B5oF7w4CzLf-8hhNcpmaw85HdLPpgn_Iljf_DXGDH9durnGPaRuWOGaWhpnEDZiva89rzawCEJIpcQvSJqdO</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Jha, Menka</creator><creator>Jhunjhunwala, Ketan</creator><creator>Sankara, Bagepally B</creator><creator>Saini, Jitender</creator><creator>Kumar, J. Keshav</creator><creator>Yadav, Ravi</creator><creator>Pal, Pramod Kumar</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0856-767X</orcidid></search><sort><creationdate>20151001</creationdate><title>Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait</title><author>Jha, Menka ; Jhunjhunwala, Ketan ; Sankara, Bagepally B ; Saini, Jitender ; Kumar, J. Keshav ; Yadav, Ravi ; Pal, Pramod Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-3a082cb8f2488c0c4e989139ebe48673d52464db0ef370fa2d4ead2aa5b633463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Atrophy</topic><topic>Female</topic><topic>Freezing of gait</topic><topic>Gait</topic><topic>Gait Disorders, Neurologic - etiology</topic><topic>Gait Disorders, Neurologic - pathology</topic><topic>Gait Disorders, Neurologic - psychology</topic><topic>Gray Matter - pathology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological assessment</topic><topic>Neuropsychological Tests</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson's disease</topic><topic>Voxel based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jha, Menka</creatorcontrib><creatorcontrib>Jhunjhunwala, Ketan</creatorcontrib><creatorcontrib>Sankara, Bagepally B</creatorcontrib><creatorcontrib>Saini, Jitender</creatorcontrib><creatorcontrib>Kumar, J. Keshav</creatorcontrib><creatorcontrib>Yadav, Ravi</creatorcontrib><creatorcontrib>Pal, Pramod Kumar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jha, Menka</au><au>Jhunjhunwala, Ketan</au><au>Sankara, Bagepally B</au><au>Saini, Jitender</au><au>Kumar, J. Keshav</au><au>Yadav, Ravi</au><au>Pal, Pramod Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>21</volume><issue>10</issue><spage>1184</spage><epage>1190</epage><pages>1184-1190</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract Background Neuropsychological evaluation with advanced neuroimaging may be a useful tool to determine the anatomical substrates that play crucial role in freezing of gait (FOG) in patients with Parkinson's Disease (PD). Objectives To compare the cognitive profile and gray matter (GM) changes (using Voxel Based Morphometry – VBM) between patients with PD with and without FOG (FOG+ve and FOG−ve). Methods Seventeen FOG+ve (M:F = 11:6) and 21 FOG−ve (M:F = 11:10) were evaluated clinically and with a structured neuropsychological battery. All patients underwent 3 T MRI. In order to determine areas of GM atrophy, T1W volumetric MRI data of the two groups were compared using VBM and Statistical Parametric Mapping 8. Results The mean age of FOG+ve and FOG−ve patients were 56.9 ± 6.6 and 47.4 ± 9.1 years respectively. There was no significant difference in the duration (6.0 ± 4.9 vs 5.2 ± 3.5 years, p < 0.05) and stage of PD (Hoehn & Yahr stage: 1.96 ± 0.53 vs 1.78 ± 0.37) between the two groups. Compared to the FOG−ve group, the FOG+ve group had (i) significant impairment in memory, attention, executive and visuospatial functions on neuropsychological tests, and (ii) significant GM atrophy in the right cerebellum (pyramis, declive), left cerebrum (Brodmann area (BA) 21 and 22) and right cerebrum (BA 10 and 6) on VBM analysis. Conclusions The FOG+ve group showed widespread involvement of cognition localizing to frontal, temporal (especially left) and parietal areas. VBM analysis showed significant GM atrophy in FOG+ve group in left temporal, right frontal areas (coinciding with that observed in neuropsychological tests) and significant involvement of right cerebellum.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26305999</pmid><doi>10.1016/j.parkreldis.2015.08.009</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0856-767X</orcidid></addata></record> |
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| subjects | Atrophy Female Freezing of gait Gait Gait Disorders, Neurologic - etiology Gait Disorders, Neurologic - pathology Gait Disorders, Neurologic - psychology Gray Matter - pathology Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Neurology Neuropsychological assessment Neuropsychological Tests Parkinson Disease - complications Parkinson Disease - pathology Parkinson Disease - psychology Parkinson's disease Voxel based morphometry |
| title | Neuropsychological and imaging profile of patients with Parkinson's disease and freezing of gait |
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