Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation

Two kinds of cinnamaldehyde derivative, 2′-hydroxycinnamaldehyde (HCA) and 2′-benzoxycinnamaldehyde (BCA), were studied for their immunomodulatory effects. These compounds were screened as anticancer drug candidates from stem bark of Cinnamomum cassia for their inhibitory effect on farnesyl protein...

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Veröffentlicht in:	International journal of immunopharmacology 1998-11, Vol.20 (11), p.643-660
Hauptverfasser:	Koh, W.S, Yoon, S.Y, Kwon, B.M, Jeong, T.C, Nam, K.S, Han, M.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Alkyl and Aryl Transferases - antagonists & inhibitors Animals Biological and medical sciences CD4 Antigens - biosynthesis CD8 Antigens - biosynthesis Cell Cycle - drug effects Cell cycle progression Cell Differentiation - drug effects Cinnamaldehyde Cinnamates - pharmacology Concanavalin A - pharmacology Differentiation Enzyme Inhibitors - pharmacology Farnesyltranstransferase FPTase Immunoglobulin M - biosynthesis Immunoglobulin M - physiology Immunomodulators Immunosuppression Lymphocyte Activation - drug effects Lymphokine production Lymphokines - metabolism Lymphoproliferation Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Sensitivity and Specificity Spleen - cytology Spleen - metabolism T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology
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