Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations

An updated PBPK model of methylene chloride (DCM, dichloromethane) carcinogenicity in mice was recently published using Bayesian statistical methods ( Marino et al., 2006). In this work, this model was applied to humans, as recommended by Sweeney et al. (2004). Physiological parameters for input int...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Regulatory toxicology and pharmacology 2006-06, Vol.45 (1), p.55-65
Hauptverfasser:	David, Raymond M., Clewell, Harvey J., Gentry, P. Robinan, Covington, Tammie R., Morgott, David A., Marino, Dale J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian analysis Carcinogens - pharmacokinetics Carcinogens - toxicity Dichloromethane Dose-Response Relationship, Drug Glutathione Transferase - genetics GST polymorphism Humans Inhalation Exposure Markov Chains Methylene chloride Methylene Chloride - pharmacokinetics Methylene Chloride - toxicity Models, Biological Monte Carlo analysis Monte Carlo Method Neoplasms - chemically induced Neoplasms - genetics PBPK modeling Polymorphism, Genetic Risk Assessment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!