Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding
Objective Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Se...
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| creator | Batistuzzo, Marcelo Camargo, PsyD, PhD Balardin, Joana Bisol, PhD Martin, Maria da Graça Morais, MD, PhD Hoexter, Marcelo Queiroz, MD, PhD Bernardes, Elisa Teixeira, PsyD Borcato, Sonia, PsyD Souza, Marina de Marco e, PsyD Querido, Cicero Nardini, MD Morais, Rosa Magaly, MD de Alvarenga, Pedro Gomes, MD Lopes, Antonio Carlos, MD Shavitt, Roseli Gedanke, MD, PhD Savage, Cary R., PhD Amaro, Edson, MD, PhD Miguel, Euripedes C., MD, PhD Polanczyk, Guilherme V., MD, PhD Miotto, Eliane C., PsyD, PhD |
| description | Objective Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)–encoding paradigm. Method A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results The semantic clustering strategy score (SCS) predicted VEM performance in HC ( p < .001, R2 = 0.635), but not in patients ( p = .099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p < .001). Within-group analysis revealed a negative correlation between Yale–Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC ( p = .001, r = 0.635), but not in patients with OCD ( p = .936, r = 0.017). Conclusion Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD. |
| doi_str_mv | 10.1016/j.jaac.2015.06.020 |
| format | Article |
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Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)–encoding paradigm. Method A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results The semantic clustering strategy score (SCS) predicted VEM performance in HC ( p < .001, R2 = 0.635), but not in patients ( p = .099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p < .001). Within-group analysis revealed a negative correlation between Yale–Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC ( p = .001, r = 0.635), but not in patients with OCD ( p = .936, r = 0.017). Conclusion Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1016/j.jaac.2015.06.020</identifier><identifier>PMID: 26407495</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Brain Mapping ; Brazil ; Child ; Cross-Sectional Studies ; Female ; functional magnetic resonance imaging ; Humans ; Linear Models ; Magnetic Resonance Imaging ; Male ; Memory, Episodic ; obsessive-compulsive disorder ; Obsessive-Compulsive Disorder - physiopathology ; Pediatrics ; Prefrontal Cortex - physiopathology ; Psychiatry ; semantic clustering ; Semantics ; verbal episodic memory</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2015-10, Vol.54 (10), p.849-858</ispartof><rights>American Academy of Child and Adolescent Psychiatry</rights><rights>2015 American Academy of Child and Adolescent Psychiatry</rights><rights>Copyright © 2015 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-7d00d0c179a436999aede7a1666487490e1338eebed83a39d895cc823428a1383</citedby><cites>FETCH-LOGICAL-c481t-7d00d0c179a436999aede7a1666487490e1338eebed83a39d895cc823428a1383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaac.2015.06.020$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26407495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batistuzzo, Marcelo Camargo, PsyD, PhD</creatorcontrib><creatorcontrib>Balardin, Joana Bisol, PhD</creatorcontrib><creatorcontrib>Martin, Maria da Graça Morais, MD, PhD</creatorcontrib><creatorcontrib>Hoexter, Marcelo Queiroz, MD, PhD</creatorcontrib><creatorcontrib>Bernardes, Elisa Teixeira, PsyD</creatorcontrib><creatorcontrib>Borcato, Sonia, PsyD</creatorcontrib><creatorcontrib>Souza, Marina de Marco e, PsyD</creatorcontrib><creatorcontrib>Querido, Cicero Nardini, MD</creatorcontrib><creatorcontrib>Morais, Rosa Magaly, MD</creatorcontrib><creatorcontrib>de Alvarenga, Pedro Gomes, MD</creatorcontrib><creatorcontrib>Lopes, Antonio Carlos, MD</creatorcontrib><creatorcontrib>Shavitt, Roseli Gedanke, MD, PhD</creatorcontrib><creatorcontrib>Savage, Cary R., PhD</creatorcontrib><creatorcontrib>Amaro, Edson, MD, PhD</creatorcontrib><creatorcontrib>Miguel, Euripedes C., MD, PhD</creatorcontrib><creatorcontrib>Polanczyk, Guilherme V., MD, PhD</creatorcontrib><creatorcontrib>Miotto, Eliane C., PsyD, PhD</creatorcontrib><title>Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>Objective Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)–encoding paradigm. Method A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results The semantic clustering strategy score (SCS) predicted VEM performance in HC ( p < .001, R2 = 0.635), but not in patients ( p = .099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p < .001). Within-group analysis revealed a negative correlation between Yale–Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC ( p = .001, r = 0.635), but not in patients with OCD ( p = .936, r = 0.017). Conclusion Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD.</description><subject>Adolescent</subject><subject>Brain Mapping</subject><subject>Brazil</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory, Episodic</subject><subject>obsessive-compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - physiopathology</subject><subject>Pediatrics</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatry</subject><subject>semantic clustering</subject><subject>Semantics</subject><subject>verbal episodic memory</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS1ERYeBP8ACeckm4ToPx5EQUjUdWqSijqDA0vLYt8Uhsad2MtIs-O91NC0LFqzuQ-cc6X6XkDcMcgaMv-_yTimdF8DqHHgOBTwjC1YXTVZXTDwnCxAtZKLmzSl5GWMHAKwR4gU5LXgFTdXWC_LnK5pJo6GbgLfBu1H19EyPdq9G6x21jm7QWDUGq-km7dCNkf604y96vY0Yo91jtvLDburnlp7b6IPBQM-nYN0d_YFhmxLXu7Q3KeILDj4c6NrpNLq7V-TkVvURXz_WJfn-aX2zusyuri8-r86uMl0JNmaNATCgWdOqquRt2yo02CjGOa9EugOQlaVA3KIRpSpbI9paa1GUVSEUK0W5JO-Oubvg7yeMoxxs1Nj3yqGfomQN423FWLIsSXGU6uBjTFDkLthBhYNkIGfsspMzdjljl8Blwp5Mbx_zp-2A5q_liXMSfDgKMF25txhk1IllAm8D6lEab_-f__Efu-6ts1r1v_GAsfNTcImfZDIWEuS3-fHz31kNUNWNKB8AZyipZg</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Batistuzzo, Marcelo Camargo, PsyD, PhD</creator><creator>Balardin, Joana Bisol, PhD</creator><creator>Martin, Maria da Graça Morais, MD, PhD</creator><creator>Hoexter, Marcelo Queiroz, MD, PhD</creator><creator>Bernardes, Elisa Teixeira, PsyD</creator><creator>Borcato, Sonia, PsyD</creator><creator>Souza, Marina de Marco e, PsyD</creator><creator>Querido, Cicero Nardini, MD</creator><creator>Morais, Rosa Magaly, MD</creator><creator>de Alvarenga, Pedro Gomes, MD</creator><creator>Lopes, Antonio Carlos, MD</creator><creator>Shavitt, Roseli Gedanke, MD, PhD</creator><creator>Savage, Cary R., PhD</creator><creator>Amaro, Edson, MD, PhD</creator><creator>Miguel, Euripedes C., MD, PhD</creator><creator>Polanczyk, Guilherme V., MD, PhD</creator><creator>Miotto, Eliane C., PsyD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding</title><author>Batistuzzo, Marcelo Camargo, PsyD, PhD ; Balardin, Joana Bisol, PhD ; Martin, Maria da Graça Morais, MD, PhD ; Hoexter, Marcelo Queiroz, MD, PhD ; Bernardes, Elisa Teixeira, PsyD ; Borcato, Sonia, PsyD ; Souza, Marina de Marco e, PsyD ; Querido, Cicero Nardini, MD ; Morais, Rosa Magaly, MD ; de Alvarenga, Pedro Gomes, MD ; Lopes, Antonio Carlos, MD ; Shavitt, Roseli Gedanke, MD, PhD ; Savage, Cary R., PhD ; Amaro, Edson, MD, PhD ; Miguel, Euripedes C., MD, PhD ; Polanczyk, Guilherme V., MD, PhD ; Miotto, Eliane C., PsyD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-7d00d0c179a436999aede7a1666487490e1338eebed83a39d895cc823428a1383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Brain Mapping</topic><topic>Brazil</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Memory, Episodic</topic><topic>obsessive-compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - physiopathology</topic><topic>Pediatrics</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatry</topic><topic>semantic clustering</topic><topic>Semantics</topic><topic>verbal episodic memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batistuzzo, Marcelo Camargo, PsyD, PhD</creatorcontrib><creatorcontrib>Balardin, Joana Bisol, PhD</creatorcontrib><creatorcontrib>Martin, Maria da Graça Morais, MD, PhD</creatorcontrib><creatorcontrib>Hoexter, Marcelo Queiroz, MD, PhD</creatorcontrib><creatorcontrib>Bernardes, Elisa Teixeira, PsyD</creatorcontrib><creatorcontrib>Borcato, Sonia, PsyD</creatorcontrib><creatorcontrib>Souza, Marina de Marco e, PsyD</creatorcontrib><creatorcontrib>Querido, Cicero Nardini, MD</creatorcontrib><creatorcontrib>Morais, Rosa Magaly, MD</creatorcontrib><creatorcontrib>de Alvarenga, Pedro Gomes, MD</creatorcontrib><creatorcontrib>Lopes, Antonio Carlos, MD</creatorcontrib><creatorcontrib>Shavitt, Roseli Gedanke, MD, PhD</creatorcontrib><creatorcontrib>Savage, Cary R., PhD</creatorcontrib><creatorcontrib>Amaro, Edson, MD, PhD</creatorcontrib><creatorcontrib>Miguel, Euripedes C., MD, PhD</creatorcontrib><creatorcontrib>Polanczyk, Guilherme V., MD, PhD</creatorcontrib><creatorcontrib>Miotto, Eliane C., PsyD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batistuzzo, Marcelo Camargo, PsyD, PhD</au><au>Balardin, Joana Bisol, PhD</au><au>Martin, Maria da Graça Morais, MD, PhD</au><au>Hoexter, Marcelo Queiroz, MD, PhD</au><au>Bernardes, Elisa Teixeira, PsyD</au><au>Borcato, Sonia, PsyD</au><au>Souza, Marina de Marco e, PsyD</au><au>Querido, Cicero Nardini, MD</au><au>Morais, Rosa Magaly, MD</au><au>de Alvarenga, Pedro Gomes, MD</au><au>Lopes, Antonio Carlos, MD</au><au>Shavitt, Roseli Gedanke, MD, PhD</au><au>Savage, Cary R., PhD</au><au>Amaro, Edson, MD, PhD</au><au>Miguel, Euripedes C., MD, PhD</au><au>Polanczyk, Guilherme V., MD, PhD</au><au>Miotto, Eliane C., PsyD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>54</volume><issue>10</issue><spage>849</spage><epage>858</epage><pages>849-858</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><abstract>Objective Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)–encoding paradigm. Method A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results The semantic clustering strategy score (SCS) predicted VEM performance in HC ( p < .001, R2 = 0.635), but not in patients ( p = .099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p < .001). Within-group analysis revealed a negative correlation between Yale–Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC ( p = .001, r = 0.635), but not in patients with OCD ( p = .936, r = 0.017). Conclusion Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26407495</pmid><doi>10.1016/j.jaac.2015.06.020</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Brain Mapping Brazil Child Cross-Sectional Studies Female functional magnetic resonance imaging Humans Linear Models Magnetic Resonance Imaging Male Memory, Episodic obsessive-compulsive disorder Obsessive-Compulsive Disorder - physiopathology Pediatrics Prefrontal Cortex - physiopathology Psychiatry semantic clustering Semantics verbal episodic memory |
| title | Reduced Prefrontal Activation in Pediatric Patients With Obsessive-Compulsive Disorder During Verbal Episodic Memory Encoding |
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