Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats

Comorbidity between mood disorders and cardiovascular disease has been described extensively. However, available antidepressants can have cardiovascular side effects. Treatment with selective inhibitors of neuronal nitric oxide synthase (nNOS) induces antidepressant effects, but whether the antidepr...

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Veröffentlicht in:	Stress (Amsterdam, Netherlands) Netherlands), 2015-01, Vol.18 (4), p.462-474
Hauptverfasser:	Almeida, Jeferson, Duarte, Josiane O, Oliveira, Leandro A, Crestani, Carlos C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Autonomic Nervous System - drug effects Baroreflex - drug effects Behavior, Animal - drug effects Cardiovascular System - drug effects Chronic Disease Corticosterone - blood Depression - blood Depression - psychology Enzyme Inhibitors - pharmacology Fluoxetine - pharmacology Indazoles - pharmacology Male Nitric Oxide Synthase Type I - antagonists & inhibitors Rats Rats, Wistar Stress, Psychological - blood Stress, Psychological - psychology Swimming Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology Weight Gain - drug effects
Online-Zugang:	Volltext
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