Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis
Abstract Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized sample...
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| Veröffentlicht in: | Parasitology international 2015-12, Vol.64 (6), p.591-596 |
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| creator | Mishra, Anshuman Antony, Justin S Gai, Prabhanjan Sundaravadivel, Pandarisamy Hoang van, Tong Jha, Aditya Nath Singh, Lalji Velavan, Thirumalaisamy P Thangaraj, Kumarasamy |
| description | Abstract Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P = 0.007). The MBL 2 promoter variants − 78C/T and + 4P/Q were significantly associated with relative protection to VL (− 78C/T, OR = 0.7, 95% CI = 0.5–0.96, adjusted P = 0.026 and + 4P/Q, OR = 0.66, 95% CI = 0.48–0.9, adjusted P = 0.012). MBL2 * LYQA haplotypes occurred frequently among controls (OR = 0.69, 95% CI = 0.5–0.97, adjusted P = 0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL. |
| doi_str_mv | 10.1016/j.parint.2015.08.003 |
| format | Article |
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Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P = 0.007). The MBL 2 promoter variants − 78C/T and + 4P/Q were significantly associated with relative protection to VL (− 78C/T, OR = 0.7, 95% CI = 0.5–0.96, adjusted P = 0.026 and + 4P/Q, OR = 0.66, 95% CI = 0.48–0.9, adjusted P = 0.012). MBL2 * LYQA haplotypes occurred frequently among controls (OR = 0.69, 95% CI = 0.5–0.97, adjusted P = 0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL.</description><identifier>ISSN: 1383-5769</identifier><identifier>EISSN: 1873-0329</identifier><identifier>DOI: 10.1016/j.parint.2015.08.003</identifier><identifier>PMID: 26297290</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Case-Control Studies ; Complement System Proteins - immunology ; Cross-Sectional Studies ; Female ; Gastroenterology and Hepatology ; Gene Frequency - genetics ; Genotype ; Humans ; India ; Infectious Disease ; Leishmania donovani ; Leishmania donovani - immunology ; Leishmaniasis, Visceral - immunology ; Leishmaniasis, Visceral - parasitology ; Leishmaniasis, Visceral - pathology ; Male ; Mannose-Binding Lectin - blood ; Mannose-Binding Lectin - genetics ; Mannose-Binding Lectin - metabolism ; MBL serum level ; MBL2 ; Polymorphism, Single Nucleotide - genetics ; Promoter Regions, Genetic - genetics ; Visceral Leishmaniasis</subject><ispartof>Parasitology international, 2015-12, Vol.64 (6), p.591-596</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-528f2b286258b6f27c5aabac89712ec3d86cba6c8752b98698cc27304927b8943</citedby><cites>FETCH-LOGICAL-c441t-528f2b286258b6f27c5aabac89712ec3d86cba6c8752b98698cc27304927b8943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S138357691500135X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26297290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishra, Anshuman</creatorcontrib><creatorcontrib>Antony, Justin S</creatorcontrib><creatorcontrib>Gai, Prabhanjan</creatorcontrib><creatorcontrib>Sundaravadivel, Pandarisamy</creatorcontrib><creatorcontrib>Hoang van, Tong</creatorcontrib><creatorcontrib>Jha, Aditya Nath</creatorcontrib><creatorcontrib>Singh, Lalji</creatorcontrib><creatorcontrib>Velavan, Thirumalaisamy P</creatorcontrib><creatorcontrib>Thangaraj, Kumarasamy</creatorcontrib><title>Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis</title><title>Parasitology international</title><addtitle>Parasitol Int</addtitle><description>Abstract Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P = 0.007). The MBL 2 promoter variants − 78C/T and + 4P/Q were significantly associated with relative protection to VL (− 78C/T, OR = 0.7, 95% CI = 0.5–0.96, adjusted P = 0.026 and + 4P/Q, OR = 0.66, 95% CI = 0.48–0.9, adjusted P = 0.012). MBL2 * LYQA haplotypes occurred frequently among controls (OR = 0.69, 95% CI = 0.5–0.97, adjusted P = 0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL.</description><subject>Case-Control Studies</subject><subject>Complement System Proteins - immunology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gene Frequency - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>India</subject><subject>Infectious Disease</subject><subject>Leishmania donovani</subject><subject>Leishmania donovani - immunology</subject><subject>Leishmaniasis, Visceral - immunology</subject><subject>Leishmaniasis, Visceral - parasitology</subject><subject>Leishmaniasis, Visceral - pathology</subject><subject>Male</subject><subject>Mannose-Binding Lectin - blood</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Mannose-Binding Lectin - metabolism</subject><subject>MBL serum level</subject><subject>MBL2</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Visceral Leishmaniasis</subject><issn>1383-5769</issn><issn>1873-0329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtP3DAURi3Uimf_Aaq8hEVSPxI_NpUKKi3SIBbQqjvLdpziacYZfBMk_n0dDXTRDSt7cb7v2ucidEpJTQkVn9b11uaYppoR2tZE1YTwPXRIleQV4Uy_K3eueNVKoQ_QEcCaFFBKuo8OmGBaMk0Okb-xKY0QKhdTF9NvvAp-igmf3VyszrEFbDHM4MN2im4I-GGECffWT2PGMfXDHJJfUtclbBP-GQua7VBaIjxsbIoWIpyg970dIHx4OY_Rj6uv95ffq9Xtt-vLL6vKNw2dqpapnjmmBGuVEz2TvrXWWa-0pCx43inhnRVeyZY5rYRW3jPJSaOZdEo3_Bid7Xq3eXycA0xms7xnGGwK4wyGSio0L350QZsd6vMIkENvtjlubH42lJhFr1mbnV6z6DVEmaK3xD6-TJjdJnT_Qq8-C_B5B4Tyz6cYsgEfi6PQxVzEmm6Mb034v8APMUVvhz_hOcB6nHMqDg01wAwxd8uKlw3TtmyXt7_4X7Irojo</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Mishra, Anshuman</creator><creator>Antony, Justin S</creator><creator>Gai, Prabhanjan</creator><creator>Sundaravadivel, Pandarisamy</creator><creator>Hoang van, Tong</creator><creator>Jha, Aditya Nath</creator><creator>Singh, Lalji</creator><creator>Velavan, Thirumalaisamy P</creator><creator>Thangaraj, Kumarasamy</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis</title><author>Mishra, Anshuman ; Antony, Justin S ; Gai, Prabhanjan ; Sundaravadivel, Pandarisamy ; Hoang van, Tong ; Jha, Aditya Nath ; Singh, Lalji ; Velavan, Thirumalaisamy P ; Thangaraj, Kumarasamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-528f2b286258b6f27c5aabac89712ec3d86cba6c8752b98698cc27304927b8943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Case-Control Studies</topic><topic>Complement System Proteins - immunology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Gene Frequency - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>India</topic><topic>Infectious Disease</topic><topic>Leishmania donovani</topic><topic>Leishmania donovani - immunology</topic><topic>Leishmaniasis, Visceral - immunology</topic><topic>Leishmaniasis, Visceral - parasitology</topic><topic>Leishmaniasis, Visceral - pathology</topic><topic>Male</topic><topic>Mannose-Binding Lectin - blood</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Mannose-Binding Lectin - metabolism</topic><topic>MBL serum level</topic><topic>MBL2</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Visceral Leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, Anshuman</creatorcontrib><creatorcontrib>Antony, Justin S</creatorcontrib><creatorcontrib>Gai, Prabhanjan</creatorcontrib><creatorcontrib>Sundaravadivel, Pandarisamy</creatorcontrib><creatorcontrib>Hoang van, Tong</creatorcontrib><creatorcontrib>Jha, Aditya Nath</creatorcontrib><creatorcontrib>Singh, Lalji</creatorcontrib><creatorcontrib>Velavan, Thirumalaisamy P</creatorcontrib><creatorcontrib>Thangaraj, Kumarasamy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, Anshuman</au><au>Antony, Justin S</au><au>Gai, Prabhanjan</au><au>Sundaravadivel, Pandarisamy</au><au>Hoang van, Tong</au><au>Jha, Aditya Nath</au><au>Singh, Lalji</au><au>Velavan, Thirumalaisamy P</au><au>Thangaraj, Kumarasamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis</atitle><jtitle>Parasitology international</jtitle><addtitle>Parasitol Int</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>64</volume><issue>6</issue><spage>591</spage><epage>596</epage><pages>591-596</pages><issn>1383-5769</issn><eissn>1873-0329</eissn><abstract>Abstract Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215 healthy controls from an Indian population. MBL2 functional variants were genotyped and the circulating MBL serum levels were measured. MBL serum levels were elevated in patients compared to the healthy controls (adjusted P = 0.007). The MBL 2 promoter variants − 78C/T and + 4P/Q were significantly associated with relative protection to VL (− 78C/T, OR = 0.7, 95% CI = 0.5–0.96, adjusted P = 0.026 and + 4P/Q, OR = 0.66, 95% CI = 0.48–0.9, adjusted P = 0.012). MBL2 * LYQA haplotypes occurred frequently among controls (OR = 0.69, 95% CI = 0.5–0.97, adjusted P = 0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26297290</pmid><doi>10.1016/j.parint.2015.08.003</doi><tpages>6</tpages></addata></record> |
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| subjects | Case-Control Studies Complement System Proteins - immunology Cross-Sectional Studies Female Gastroenterology and Hepatology Gene Frequency - genetics Genotype Humans India Infectious Disease Leishmania donovani Leishmania donovani - immunology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - pathology Male Mannose-Binding Lectin - blood Mannose-Binding Lectin - genetics Mannose-Binding Lectin - metabolism MBL serum level MBL2 Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic - genetics Visceral Leishmaniasis |
| title | Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis |
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