Simultaneous quantitation of delamanid (OPC-67683) and its eight metabolites in human plasma using UHPLC–MS/MS

•Delamanid (OPC-67683) is a new drug developed to treat tuberculosis (TB).•An UHPLC–MS/MS method was developed to quantify delamanid and its eight metabolites.•This method has been used to support multiple regulated clinic studies. Delamanid (OPC-67683) is a novel nitro-dihydroimidazo-oxazole deriva...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2015-10, Vol.1002, p.78-91
Hauptverfasser:	Meng, Min, Smith, Benjamin, Johnston, Brad, Carter, Spencer, Brisson, Jerry, Roth, Sharin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods Delamanid (code-named OPC-67683) Double-Blind Method Human plasma Humans Limit of Detection Nitroimidazoles - blood Oxazoles - blood Placebos Reproducibility of Results Selected reaction monitoring (SRM) Tandem Mass Spectrometry - methods Tuberculosis Ultra-high performance liquid chromatography and tandem mass spectrometry (UHPLC–MS/MS)
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