Combined Lysis of Thrombus with Ultrasound and Systemic Tissue Plasminogen Activator for Emergent Revascularization in Acute Ischemic Stroke (Clotbust-ER): Design and Methodology of a Multinational Phase 3 Trial

Background We designed a Phase 3 clinical trial to determine the safety and efficacy of adding transcranial ultrasound using an operator-independent headframe to recombinant tissue-plasminogen-activator for the treatment of acute ischemic stroke. Methods Combined lysis of thrombus with ultrasound an...

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Veröffentlicht in:	International journal of stroke 2015-10, Vol.10 (7), p.1141-1148
Hauptverfasser:	Schellinger, Peter D., Alexandrov, Andrei V., Barreto, Andrew D., Demchuk, Andrew M., Tsivgoulis, Georgios, Kohrmann, Martin, Alleman, John, Howard, Virginia, Howard, George, Alexandrov, Anne W., Brandt, Gordon, Molina, Carlos A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute stroke therapy Adolescent Adult Aged Aged, 80 and over Blood clots Brain Ischemia - complications Brain Ischemia - therapy clinical trial Clinical trials Double-Blind Method Female fibrinolysis Fibrinolytic Agents - therapeutic use Humans Logistic Models Male Middle Aged Prospective Studies rt‐PA Severity of Illness Index sonolysis Statistics, Nonparametric Stroke Stroke - etiology Stroke - therapy thrombolysis Tissue Plasminogen Activator - therapeutic use Treatment Outcome Ultrasonic imaging Ultrasonic Therapy - methods ultrasound Young Adult
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