An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria
Background Cold‐ and heat‐induced urticaria are chronic physical urticaria conditions in which wheals, angioedema or both are evoked by skin exposure to cold and heat respectively. The diagnostic work up of both conditions should include skin provocation tests and accurate determination of critical...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2015-10, Vol.29 (10), p.2043-2045 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
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| creator | Magerl, M. Abajian, M. Krause, K. Altrichter, S. Siebenhaar, F. Church, M.K. |
| description | Background
Cold‐ and heat‐induced urticaria are chronic physical urticaria conditions in which wheals, angioedema or both are evoked by skin exposure to cold and heat respectively. The diagnostic work up of both conditions should include skin provocation tests and accurate determination of critical temperature thresholds (CTT) for producing symptoms in order to be able to predict the potential risk that each individual patient faces and how this may be ameliorated by therapy.
Objective
To develop and validate TempTest® 4, a simple and relatively inexpensive instrument for the accurate determination of CTT which may be used in clinical practice.
Methods
TempTest® 4 has a single 2 mm wide 350 mm U‐shaped Peltier element generating a temperature gradient from 4 °C to 44 °C along its length. Using a clear plastic guide placed over the skin after provocation, CTT values may be determined with an accuracy of ±1 °C. Here, TempTest® 4 was compared with its much more expensive predecessor, TempTest® 3, in inducing wheals in 30 cold urticaria patients.
Results
Both TempTest® 4 and TempTest® 3 induced wheals in all 30 patients between 8 ° and 28 °C. There was a highly significant (P |
| doi_str_mv | 10.1111/jdv.12739 |
| format | Article |
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Cold‐ and heat‐induced urticaria are chronic physical urticaria conditions in which wheals, angioedema or both are evoked by skin exposure to cold and heat respectively. The diagnostic work up of both conditions should include skin provocation tests and accurate determination of critical temperature thresholds (CTT) for producing symptoms in order to be able to predict the potential risk that each individual patient faces and how this may be ameliorated by therapy.
Objective
To develop and validate TempTest® 4, a simple and relatively inexpensive instrument for the accurate determination of CTT which may be used in clinical practice.
Methods
TempTest® 4 has a single 2 mm wide 350 mm U‐shaped Peltier element generating a temperature gradient from 4 °C to 44 °C along its length. Using a clear plastic guide placed over the skin after provocation, CTT values may be determined with an accuracy of ±1 °C. Here, TempTest® 4 was compared with its much more expensive predecessor, TempTest® 3, in inducing wheals in 30 cold urticaria patients.
Results
Both TempTest® 4 and TempTest® 3 induced wheals in all 30 patients between 8 ° and 28 °C. There was a highly significant (P < 0.0001) correlation between the instruments in the CTT values in individual patients.
Conclusion
The TempTest® 4 is a simple, easy to use, licensed, commercially available and affordable instrument for the determination of CTTs in both cold‐ and heat‐induced urticaria.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.12739</identifier><identifier>PMID: 25266078</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Case-Control Studies ; Cold Temperature - adverse effects ; Female ; Hot Temperature - adverse effects ; Humans ; Male ; Middle Aged ; Skin Temperature ; Skin Tests - instrumentation ; Urticaria - etiology ; Urticaria - physiopathology ; Young Adult</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2015-10, Vol.29 (10), p.2043-2045</ispartof><rights>2014 European Academy of Dermatology and Venereology</rights><rights>2014 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4999-9a7646ba8575e7b111c39b4627b28d4e152d1127131077132e0130ad2b58d0b83</citedby><cites>FETCH-LOGICAL-c4999-9a7646ba8575e7b111c39b4627b28d4e152d1127131077132e0130ad2b58d0b83</cites><orcidid>0000-0002-1639-9410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.12739$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.12739$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25266078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Magerl, M.</creatorcontrib><creatorcontrib>Abajian, M.</creatorcontrib><creatorcontrib>Krause, K.</creatorcontrib><creatorcontrib>Altrichter, S.</creatorcontrib><creatorcontrib>Siebenhaar, F.</creatorcontrib><creatorcontrib>Church, M.K.</creatorcontrib><title>An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
Cold‐ and heat‐induced urticaria are chronic physical urticaria conditions in which wheals, angioedema or both are evoked by skin exposure to cold and heat respectively. The diagnostic work up of both conditions should include skin provocation tests and accurate determination of critical temperature thresholds (CTT) for producing symptoms in order to be able to predict the potential risk that each individual patient faces and how this may be ameliorated by therapy.
Objective
To develop and validate TempTest® 4, a simple and relatively inexpensive instrument for the accurate determination of CTT which may be used in clinical practice.
Methods
TempTest® 4 has a single 2 mm wide 350 mm U‐shaped Peltier element generating a temperature gradient from 4 °C to 44 °C along its length. Using a clear plastic guide placed over the skin after provocation, CTT values may be determined with an accuracy of ±1 °C. Here, TempTest® 4 was compared with its much more expensive predecessor, TempTest® 3, in inducing wheals in 30 cold urticaria patients.
Results
Both TempTest® 4 and TempTest® 3 induced wheals in all 30 patients between 8 ° and 28 °C. There was a highly significant (P < 0.0001) correlation between the instruments in the CTT values in individual patients.
Conclusion
The TempTest® 4 is a simple, easy to use, licensed, commercially available and affordable instrument for the determination of CTTs in both cold‐ and heat‐induced urticaria.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Cold Temperature - adverse effects</subject><subject>Female</subject><subject>Hot Temperature - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Skin Temperature</subject><subject>Skin Tests - instrumentation</subject><subject>Urticaria - etiology</subject><subject>Urticaria - physiopathology</subject><subject>Young Adult</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPVTEURhujkSs48A-YDmVQ6OOcPoYEAR9EJUEcNj3tPrnF87i2PSgTf7uFC8zsYDf5svZK9ofQG0YPWH2H1-HmgHElzDO0Yo3URFAtnqMVNVwSY1qzg17lfE0pZazVL9EOb7mUVOkV-ns04Thu0nwDAX-DoURIGPoefCGdyzWMUy5pGWEquJ8T9imW6N2AC4wbSK4sCXBZJ8jreQh4BJdrco_HCfuaEeymgNfgColTWHx1LunOkaLbQy96N2R4_fDvou-nJ5fHH8j517OPx0fnxDfGGGKcko3snG5VC6qrN3thukZy1XEdGmAtD6w2wASjqk4OlAnqAu9aHWinxS56t_XWS38tkIsdY_YwDG6CecmWKSaNkEw3Fd3foj7NOSfo7SbF0aVby6i9q9vWuu193ZV9-6BduhHCE_nYbwUOt8DvOMDt_0320_urRyXZbsRc4M_Thks_rVRCtfbHlzNLP19c8QvV2FPxD1scmXs</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Magerl, M.</creator><creator>Abajian, M.</creator><creator>Krause, K.</creator><creator>Altrichter, S.</creator><creator>Siebenhaar, F.</creator><creator>Church, M.K.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1639-9410</orcidid></search><sort><creationdate>201510</creationdate><title>An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria</title><author>Magerl, M. ; Abajian, M. ; Krause, K. ; Altrichter, S. ; Siebenhaar, F. ; Church, M.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4999-9a7646ba8575e7b111c39b4627b28d4e152d1127131077132e0130ad2b58d0b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Cold Temperature - adverse effects</topic><topic>Female</topic><topic>Hot Temperature - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Skin Temperature</topic><topic>Skin Tests - instrumentation</topic><topic>Urticaria - etiology</topic><topic>Urticaria - physiopathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Magerl, M.</creatorcontrib><creatorcontrib>Abajian, M.</creatorcontrib><creatorcontrib>Krause, K.</creatorcontrib><creatorcontrib>Altrichter, S.</creatorcontrib><creatorcontrib>Siebenhaar, F.</creatorcontrib><creatorcontrib>Church, M.K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Magerl, M.</au><au>Abajian, M.</au><au>Krause, K.</au><au>Altrichter, S.</au><au>Siebenhaar, F.</au><au>Church, M.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2015-10</date><risdate>2015</risdate><volume>29</volume><issue>10</issue><spage>2043</spage><epage>2045</epage><pages>2043-2045</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
Cold‐ and heat‐induced urticaria are chronic physical urticaria conditions in which wheals, angioedema or both are evoked by skin exposure to cold and heat respectively. The diagnostic work up of both conditions should include skin provocation tests and accurate determination of critical temperature thresholds (CTT) for producing symptoms in order to be able to predict the potential risk that each individual patient faces and how this may be ameliorated by therapy.
Objective
To develop and validate TempTest® 4, a simple and relatively inexpensive instrument for the accurate determination of CTT which may be used in clinical practice.
Methods
TempTest® 4 has a single 2 mm wide 350 mm U‐shaped Peltier element generating a temperature gradient from 4 °C to 44 °C along its length. Using a clear plastic guide placed over the skin after provocation, CTT values may be determined with an accuracy of ±1 °C. Here, TempTest® 4 was compared with its much more expensive predecessor, TempTest® 3, in inducing wheals in 30 cold urticaria patients.
Results
Both TempTest® 4 and TempTest® 3 induced wheals in all 30 patients between 8 ° and 28 °C. There was a highly significant (P < 0.0001) correlation between the instruments in the CTT values in individual patients.
Conclusion
The TempTest® 4 is a simple, easy to use, licensed, commercially available and affordable instrument for the determination of CTTs in both cold‐ and heat‐induced urticaria.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25266078</pmid><doi>10.1111/jdv.12739</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-1639-9410</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Case-Control Studies Cold Temperature - adverse effects Female Hot Temperature - adverse effects Humans Male Middle Aged Skin Temperature Skin Tests - instrumentation Urticaria - etiology Urticaria - physiopathology Young Adult |
| title | An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria |
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