Involvement of endogenous opioid peptides in the peripheral antinociceptive effect induced by the coffee specific diterpene kahweol

Kahweol is a diterpene present in the oil derived from coffee beans. Although several pharmacological activities of kahweol are already well described in the literature, no study was done in order to assess the analgesic activity of this substance. Thus, the aim of this study was to investigate the...

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Veröffentlicht in:	Pharmacological reports 2015-10, Vol.67 (5), p.1010-1015
Hauptverfasser:	Guzzo, Luciana S., Romero, Thiago R.L., Queiroz-Junior, Celso M., Caliari, Marcelo V., Azevedo, Adolfo O., Perez, Andréa C., Duarte, Igor D.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals beta-Endorphin - biosynthesis Coffee - chemistry Coffee diterpene Dinoprostone Diterpenes - pharmacology Drug Safety and Pharmacovigilance Hyperalgesia - chemically induced Hyperalgesia - drug therapy Kahweol Leucine - analogs & derivatives Leucine - pharmacology Male Naloxone - pharmacology Narcotic Antagonists - pharmacology Opioid Peptides - pharmacology Opioid system Original Research Article Pain - chemically induced Pain - drug therapy Pain Measurement Peptides - pharmacology Peripheral antinociception Pharmacotherapy Pharmacy Pressure Rats Rats, Wistar Skin - drug effects Skin - metabolism β-Endorphin
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