Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study
Mannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause mortality in type 2 diabetes, but whether MBL is associated with mortality in type 1 diabetes remains unknown. We therefore aimed to investi...
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| Veröffentlicht in: | Diabetes care 2015-10, Vol.38 (10), p.1898-1903 |
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| creator | Østergaard, Jakob A Thiel, Steffen Lajer, Maria Steffensen, Rudi Parving, Hans-Henrik Flyvbjerg, Allan Rossing, Peter Tarnow, Lise Hansen, Troels K |
| description | Mannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause mortality in type 2 diabetes, but whether MBL is associated with mortality in type 1 diabetes remains unknown. We therefore aimed to investigate this.
We studied an existing 12-year prospective cohort with type 1 diabetes with 198 patients with diabetic nephropathy (121 men, age 41 years [95% CI 40-42], estimated glomerular filtration rate [eGFR] 67 mL/min/1.73 m(2) [95% CI 63-70]) and 174 normoalbuminuric patients (103 men, age 43 years [95% CI 41-44], eGFR 93 mL/min/1.73 m(2) [95% CI 91-95]). Mortality rates were compared according to the concentration-determining MBL2 genotype or the MBL concentration. Patients were classified as having high or low MBL expression genotypes. The effect of MBL concentration was estimated by comparing patients with MBL concentrations above or below the median.
Ninety-eight patients died during follow-up. The unadjusted hazard ratio (HR) for all-cause mortality was 1.61 (95% CI 1.07-2.43) for patients with high MBL expression genotypes versus patients with low MBL expression genotypes (P = 0.023). All-cause mortality was higher in patients with MBL concentrations above the median than in patients with MBL concentrations below the median (unadjusted HR 1.90 [95% CI 1.26-2.87], P = 0.002).
High MBL expression genotypes and high MBL concentrations are both associated with increased mortality rates in type 1 diabetes compared with low MBL expression genotypes and low MBL concentrations. |
| doi_str_mv | 10.2337/dc15-0851 |
| format | Article |
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We studied an existing 12-year prospective cohort with type 1 diabetes with 198 patients with diabetic nephropathy (121 men, age 41 years [95% CI 40-42], estimated glomerular filtration rate [eGFR] 67 mL/min/1.73 m(2) [95% CI 63-70]) and 174 normoalbuminuric patients (103 men, age 43 years [95% CI 41-44], eGFR 93 mL/min/1.73 m(2) [95% CI 91-95]). Mortality rates were compared according to the concentration-determining MBL2 genotype or the MBL concentration. Patients were classified as having high or low MBL expression genotypes. The effect of MBL concentration was estimated by comparing patients with MBL concentrations above or below the median.
Ninety-eight patients died during follow-up. The unadjusted hazard ratio (HR) for all-cause mortality was 1.61 (95% CI 1.07-2.43) for patients with high MBL expression genotypes versus patients with low MBL expression genotypes (P = 0.023). All-cause mortality was higher in patients with MBL concentrations above the median than in patients with MBL concentrations below the median (unadjusted HR 1.90 [95% CI 1.26-2.87], P = 0.002).
High MBL expression genotypes and high MBL concentrations are both associated with increased mortality rates in type 1 diabetes compared with low MBL expression genotypes and low MBL concentrations.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc15-0851</identifier><identifier>PMID: 26180106</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adult ; Carbohydrates ; Comparative analysis ; Complement Activation - physiology ; Diabetes ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes Mellitus, Type 1 - mortality ; Diabetic Nephropathies - genetics ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - mortality ; Epidemiologic Methods ; Female ; Gene expression ; Genotype ; Genotype & phenotype ; Humans ; Lectins ; Male ; Mannose-Binding Lectin - genetics ; Mannose-Binding Lectin - metabolism ; Mortality</subject><ispartof>Diabetes care, 2015-10, Vol.38 (10), p.1898-1903</ispartof><rights>2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.</rights><rights>Copyright American Diabetes Association Oct 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-b450a61f16c29559b05a4641bda57dc12f2513c0972cb6a1a8115ca3fba12d6c3</citedby><cites>FETCH-LOGICAL-c348t-b450a61f16c29559b05a4641bda57dc12f2513c0972cb6a1a8115ca3fba12d6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26180106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Østergaard, Jakob A</creatorcontrib><creatorcontrib>Thiel, Steffen</creatorcontrib><creatorcontrib>Lajer, Maria</creatorcontrib><creatorcontrib>Steffensen, Rudi</creatorcontrib><creatorcontrib>Parving, Hans-Henrik</creatorcontrib><creatorcontrib>Flyvbjerg, Allan</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Tarnow, Lise</creatorcontrib><creatorcontrib>Hansen, Troels K</creatorcontrib><title>Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Mannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause mortality in type 2 diabetes, but whether MBL is associated with mortality in type 1 diabetes remains unknown. We therefore aimed to investigate this.
We studied an existing 12-year prospective cohort with type 1 diabetes with 198 patients with diabetic nephropathy (121 men, age 41 years [95% CI 40-42], estimated glomerular filtration rate [eGFR] 67 mL/min/1.73 m(2) [95% CI 63-70]) and 174 normoalbuminuric patients (103 men, age 43 years [95% CI 41-44], eGFR 93 mL/min/1.73 m(2) [95% CI 91-95]). Mortality rates were compared according to the concentration-determining MBL2 genotype or the MBL concentration. Patients were classified as having high or low MBL expression genotypes. The effect of MBL concentration was estimated by comparing patients with MBL concentrations above or below the median.
Ninety-eight patients died during follow-up. The unadjusted hazard ratio (HR) for all-cause mortality was 1.61 (95% CI 1.07-2.43) for patients with high MBL expression genotypes versus patients with low MBL expression genotypes (P = 0.023). All-cause mortality was higher in patients with MBL concentrations above the median than in patients with MBL concentrations below the median (unadjusted HR 1.90 [95% CI 1.26-2.87], P = 0.002).
High MBL expression genotypes and high MBL concentrations are both associated with increased mortality rates in type 1 diabetes compared with low MBL expression genotypes and low MBL concentrations.</description><subject>Adult</subject><subject>Carbohydrates</subject><subject>Comparative analysis</subject><subject>Complement Activation - physiology</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Diabetes Mellitus, Type 1 - mortality</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - mortality</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Lectins</subject><subject>Male</subject><subject>Mannose-Binding Lectin - genetics</subject><subject>Mannose-Binding Lectin - metabolism</subject><subject>Mortality</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkbuO1TAQQC0EYi8LBT-ALNFAYfD4kevQoRWPlVaigTqa2M69XjlOsB0t-Qj-mUS7UFBNc-ZoNIeQl8DfCSmP750FzbjR8IgcoJWaaa3MY3LgoFqm21ZckGel3HLOlTLmKbkQDRgOvDmQ39fJZo_FO4oxMotL8XSccsUY6kpDojPW4FMt9C7UM63r7ClQF7D31ReKydFzOJ2Z_zVnX0qYEh0xJUysD8mFdKLR27p5Tj5N-3b5QJGCYKvHTIcpxumOLTMtdXHrc_JkwFj8i4d5SX58_vT96iu7-fbl-urjDbNSmcp6pTk2MEBjRat123ONqlHQO9TH7RliEBqk5e1R2L5BQAOgLcqhRxCusfKSvLn3znn6ufhSuzEU62PE5KeldHCEppVKSLWhr_9Db6clp-26nTLSGANyo97eUzZPpWQ_dHMOI-a1A97tjbq9Ubc32thXD8alH737R_6NIv8AOrCM4A</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Østergaard, Jakob A</creator><creator>Thiel, Steffen</creator><creator>Lajer, Maria</creator><creator>Steffensen, Rudi</creator><creator>Parving, Hans-Henrik</creator><creator>Flyvbjerg, Allan</creator><creator>Rossing, Peter</creator><creator>Tarnow, Lise</creator><creator>Hansen, Troels K</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study</title><author>Østergaard, Jakob A ; Thiel, Steffen ; Lajer, Maria ; Steffensen, Rudi ; Parving, Hans-Henrik ; Flyvbjerg, Allan ; Rossing, Peter ; Tarnow, Lise ; Hansen, Troels K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-b450a61f16c29559b05a4641bda57dc12f2513c0972cb6a1a8115ca3fba12d6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Carbohydrates</topic><topic>Comparative analysis</topic><topic>Complement Activation - physiology</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Diabetes Mellitus, Type 1 - mortality</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic Nephropathies - mortality</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Lectins</topic><topic>Male</topic><topic>Mannose-Binding Lectin - genetics</topic><topic>Mannose-Binding Lectin - metabolism</topic><topic>Mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Østergaard, Jakob A</creatorcontrib><creatorcontrib>Thiel, Steffen</creatorcontrib><creatorcontrib>Lajer, Maria</creatorcontrib><creatorcontrib>Steffensen, Rudi</creatorcontrib><creatorcontrib>Parving, Hans-Henrik</creatorcontrib><creatorcontrib>Flyvbjerg, Allan</creatorcontrib><creatorcontrib>Rossing, Peter</creatorcontrib><creatorcontrib>Tarnow, Lise</creatorcontrib><creatorcontrib>Hansen, Troels K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Østergaard, Jakob A</au><au>Thiel, Steffen</au><au>Lajer, Maria</au><au>Steffensen, Rudi</au><au>Parving, Hans-Henrik</au><au>Flyvbjerg, Allan</au><au>Rossing, Peter</au><au>Tarnow, Lise</au><au>Hansen, Troels K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2015-10</date><risdate>2015</risdate><volume>38</volume><issue>10</issue><spage>1898</spage><epage>1903</epage><pages>1898-1903</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Mannan-binding lectin (MBL) is a complement-activating carbohydrate-recognizing molecule associated with diabetic nephropathy. MBL is associated with all-cause mortality in type 2 diabetes, but whether MBL is associated with mortality in type 1 diabetes remains unknown. We therefore aimed to investigate this.
We studied an existing 12-year prospective cohort with type 1 diabetes with 198 patients with diabetic nephropathy (121 men, age 41 years [95% CI 40-42], estimated glomerular filtration rate [eGFR] 67 mL/min/1.73 m(2) [95% CI 63-70]) and 174 normoalbuminuric patients (103 men, age 43 years [95% CI 41-44], eGFR 93 mL/min/1.73 m(2) [95% CI 91-95]). Mortality rates were compared according to the concentration-determining MBL2 genotype or the MBL concentration. Patients were classified as having high or low MBL expression genotypes. The effect of MBL concentration was estimated by comparing patients with MBL concentrations above or below the median.
Ninety-eight patients died during follow-up. The unadjusted hazard ratio (HR) for all-cause mortality was 1.61 (95% CI 1.07-2.43) for patients with high MBL expression genotypes versus patients with low MBL expression genotypes (P = 0.023). All-cause mortality was higher in patients with MBL concentrations above the median than in patients with MBL concentrations below the median (unadjusted HR 1.90 [95% CI 1.26-2.87], P = 0.002).
High MBL expression genotypes and high MBL concentrations are both associated with increased mortality rates in type 1 diabetes compared with low MBL expression genotypes and low MBL concentrations.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>26180106</pmid><doi>10.2337/dc15-0851</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Carbohydrates Comparative analysis Complement Activation - physiology Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - mortality Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - mortality Epidemiologic Methods Female Gene expression Genotype Genotype & phenotype Humans Lectins Male Mannose-Binding Lectin - genetics Mannose-Binding Lectin - metabolism Mortality |
| title | Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study |
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