Long Noncoding RNA ANRIL Regulates Proliferation of Non-small Cell Lung Cancer and Cervical Cancer Cells

Long noncoding RNA ANRIL (antisense non-coding RNA in the INK4 locus) represses p15 and p16, which induce cell-cycle arrest at G1 phase, leading to enhanced cell proliferation of normal fibroblasts. Herein we report that ANRIL is also involved in the regulation of cancer-cell proliferation. HeLa and...

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Veröffentlicht in:	Anticancer research 2015-10, Vol.35 (10), p.5377-5382
Hauptverfasser:	Naemura, Madoka, Murasaki, Chihiro, Inoue, Yasutoshi, Okamoto, Haruna, Kotake, Yojiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle Checkpoints Cell Line, Tumor Cell Proliferation Cyclin-Dependent Kinase Inhibitor p15 - genetics Female HeLa Cells Humans Lung Neoplasms - genetics Lung Neoplasms - pathology RNA, Long Noncoding - genetics Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology
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