Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

Autophagy, an evolutionary conserved intracellular lysosome-dependent catabolic process, is an important mechanism for cellular homeostasis and survival during pathologic stress conditions in the kidney, such as ischemia-reperfusion injury (IRI). However, stimulation of autophagy has been described...

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Veröffentlicht in:	American journal of kidney diseases 2015-10, Vol.66 (4), p.699-709
Hauptverfasser:	Decuypere, Jean-Paul, PhD, Ceulemans, Laurens J., MD, Agostinis, Patrizia, PhD, Monbaliu, Diethard, MD, PhD, Naesens, Maarten, MD, PhD, Pirenne, Jacques, MD, PhD, Jochmans, Ina, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury (AKI) animal model Animals Apoptosis - physiology Autophagy Autophagy - drug effects Autophagy - physiology cell death Cells, Cultured delayed graft function Disease Models, Animal Female Graft Rejection Graft Survival Humans immunosuppression Immunosuppressive Agents - administration & dosage ischemia-reperfusion injury (IRI) kidney transplantation Kidney Transplantation - adverse effects Kidney Transplantation - methods macroautophagy Male Mice Mice, Knockout Nephrology Rats renal IRI Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reperfusion Injury - physiopathology review Risk Assessment Sensitivity and Specificity stress response
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