Delivery and therapeutic applications of gene editing technologies ZFNs, TALENs, and CRISPR/Cas9

[Display omitted] In recent years, several new genome editing technologies have been developed. Of these the zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 RNA-guided endonuclease system are the most widely described. Each of these technol...

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Veröffentlicht in:	International journal of pharmaceutics 2015-10, Vol.494 (1), p.180-194
Hauptverfasser:	LaFountaine, Justin S., Fathe, Kristin, Smyth, Hugh D.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR/Cas9 Deoxyribonucleases - genetics DNA - genetics Endodeoxyribonucleases - genetics Gene editing Genetic Therapy - methods Humans Non-viral vectors RNA - genetics RNA Editing - genetics Transcription activator-like effector nucleases Viral vectors Zinc finger nucleases Zinc Fingers - genetics
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