Inhibition of microRNA-30a prevents puromycin aminonucleoside-induced podocytic apoptosis by upregulating the glucocorticoid receptor α

It is well-established that steroid-resistant nephrotic syndrome commonly involves podocytic injury, however, the underlying mechanism remains to be elucidated. Previous studies have demonstrated that glucocorticoids enhance podocytic recovery predominantly through the functional isoform, glucocorti...

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Veröffentlicht in:	Molecular medicine reports 2015-10, Vol.12 (4), p.6043-6052
Hauptverfasser:	XIE, HUA, LIN, HONG-LI, WANG, NAN, SUN, YAN-LING, KAN, YU, GUO, HUI, CHEN, JI-LIN, FANG, MING
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Cell Differentiation Cell Line Computational Biology Corticosteroids DNA microarrays Drug therapy Gene expression Genetic aspects Glomerulonephritis glucocorticoid receptor α Glucocorticoids Health aspects Mice MicroRNA microRNA-30a MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Nephrotic syndrome podocyte Podocytes - cytology Podocytes - drug effects Podocytes - metabolism Puromycin Puromycin Aminonucleoside - toxicity Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Recovery of function Risk factors Rodents Transcription Transcriptional Activation Up-Regulation
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