Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide

Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. The aim of the present studies was to design a once weekly GLP-1 analogue by increasing albumin affinity and secure full st...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2015-09, Vol.58 (18), p.7370-7380
Hauptverfasser:	Lau, Jesper, Bloch, Paw, Schäffer, Lauge, Pettersson, Ingrid, Spetzler, Jane, Kofoed, Jacob, Madsen, Kjeld, Knudsen, Lotte Bjerre, McGuire, James, Steensgaard, Dorte Bjerre, Strauss, Holger Martin, Gram, Dorte X, Knudsen, Sanne Møller, Nielsen, Flemming Seier, Thygesen, Peter, Reedtz-Runge, Steffen, Kruse, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals Cell Line Cricetinae Crystallography, X-Ray Glucagon-Like Peptide 1 - administration & dosage Glucagon-Like Peptide 1 - analogs & derivatives Glucagon-Like Peptide 1 - chemistry Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - metabolism Glucagon-Like Peptides - administration & dosage Glucagon-Like Peptides - chemistry Glucagon-Like Peptides - pharmacology Half-Life Humans Injections, Subcutaneous Liraglutide - pharmacology Male Mice, Obese Models, Molecular Rats, Sprague-Dawley Structure-Activity Relationship Swine Swine, Miniature
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!