A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages
A mutant of Escherchia coli enterotoxin induces specific Thl-type T cells to varicella-zoster vaccine. The mutant increased IL-12p40, TNFα and nitric oxide production by IFNγ-stimulated bone marrow macrophages but cholera toxin did not. Anti-TNFα antibodies blocked its stimulation of IL-12p40 produc...
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| Veröffentlicht in: | Vaccine 2006-05, Vol.24 (18), p.3719-3726 |
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| container_issue | 18 |
| container_start_page | 3719 |
| container_title | Vaccine |
| container_volume | 24 |
| creator | Shimizu, Toshiyasu Sasaki, Keiko Kato, Michio Arimitsu, Hideyuki Ochi, Sadayuki Yano, Tomomasa Oguma, Keiji Yokochi, Takashi Tsuji, Takao |
| description | A mutant of
Escherchia coli enterotoxin induces specific Thl-type T cells to varicella-zoster vaccine. The mutant increased IL-12p40, TNFα and nitric oxide production by IFNγ-stimulated bone marrow macrophages but cholera toxin did not. Anti-TNFα antibodies blocked its stimulation of IL-12p40 production but iNOS inhibitor did not. IL-12p40 and IL-12p35 production was stimulated at the level of mRNA formation by the mutant. Cholera toxin suppressed IL-12β1 expression by spleen T cells stimulated with anti-CD3 antibodies but the mutant did not. These findings indicate that the mutant may induce Thl-type response to the vaccine through its IL-12 and TNFα induction by macrophages. |
| doi_str_mv | 10.1016/j.vaccine.2005.07.010 |
| format | Article |
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Escherchia coli enterotoxin induces specific Thl-type T cells to varicella-zoster vaccine. The mutant increased IL-12p40, TNFα and nitric oxide production by IFNγ-stimulated bone marrow macrophages but cholera toxin did not. Anti-TNFα antibodies blocked its stimulation of IL-12p40 production but iNOS inhibitor did not. IL-12p40 and IL-12p35 production was stimulated at the level of mRNA formation by the mutant. Cholera toxin suppressed IL-12β1 expression by spleen T cells stimulated with anti-CD3 antibodies but the mutant did not. These findings indicate that the mutant may induce Thl-type response to the vaccine through its IL-12 and TNFα induction by macrophages.</description><subject>Enterotoxigenic Escherichia coli</subject><subject>Escherichia coli</subject><subject>Heat-labile enterotoxin</subject><subject>IL-12</subject><subject>Macrophage</subject><subject>Mutant</subject><subject>TNFα</subject><subject>Varicella-zoster virus</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkcGO0zAQhi0EEmXhEZB84ubgcRInPaHVahcqVculSNwsdzLZuEriEDsV5Z048R4807q0d07WSP__ef75GXsPMgMJ-uMhO1pEN1KmpCwzWWUS5Au2grrKhSqhfslWUulCFCC_v2ZvQjjIJMxhvWK_b_mwRDtG7lt-H7Cj2WHnLEffO05jpNlH_9ON3I3Nkj554paHidC1Dvmu60U8TXQ27zhS3wcePT_aBEmDFb98SAR-3S_xOjsiJVFHfJp9Ikbnx7N9sxWg-P7ENw-Pf_-IEN2w9DZSwweLs586-0ThLXvV2j7Qu-t7w7493O_uvojt18-bu9utwLyQUah1jlgBtQpBpgOUa23rui0LhbRXlSaN-wYKpSlvJNiCcinzvdVQFtS0Uuc37MOFm3b8sVCIZnDhX6KR_BIMVKBrUEUSlhdhWjGEmVozzW6w88mANOdyzMFcw5tzOUZWJpWTfJ8uPkopjo5mE9BROk3jZsJoGu_-Q3gGN4meQA</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Shimizu, Toshiyasu</creator><creator>Sasaki, Keiko</creator><creator>Kato, Michio</creator><creator>Arimitsu, Hideyuki</creator><creator>Ochi, Sadayuki</creator><creator>Yano, Tomomasa</creator><creator>Oguma, Keiji</creator><creator>Yokochi, Takashi</creator><creator>Tsuji, Takao</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20060501</creationdate><title>A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages</title><author>Shimizu, Toshiyasu ; Sasaki, Keiko ; Kato, Michio ; Arimitsu, Hideyuki ; Ochi, Sadayuki ; Yano, Tomomasa ; Oguma, Keiji ; Yokochi, Takashi ; Tsuji, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-293cc71ef2c10251596a88f542ceb276e6cbd1426e3d01a4e3003ba6154edf063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Enterotoxigenic Escherichia coli</topic><topic>Escherichia coli</topic><topic>Heat-labile enterotoxin</topic><topic>IL-12</topic><topic>Macrophage</topic><topic>Mutant</topic><topic>TNFα</topic><topic>Varicella-zoster virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Toshiyasu</creatorcontrib><creatorcontrib>Sasaki, Keiko</creatorcontrib><creatorcontrib>Kato, Michio</creatorcontrib><creatorcontrib>Arimitsu, Hideyuki</creatorcontrib><creatorcontrib>Ochi, Sadayuki</creatorcontrib><creatorcontrib>Yano, Tomomasa</creatorcontrib><creatorcontrib>Oguma, Keiji</creatorcontrib><creatorcontrib>Yokochi, Takashi</creatorcontrib><creatorcontrib>Tsuji, Takao</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Toshiyasu</au><au>Sasaki, Keiko</au><au>Kato, Michio</au><au>Arimitsu, Hideyuki</au><au>Ochi, Sadayuki</au><au>Yano, Tomomasa</au><au>Oguma, Keiji</au><au>Yokochi, Takashi</au><au>Tsuji, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages</atitle><jtitle>Vaccine</jtitle><date>2006-05-01</date><risdate>2006</risdate><volume>24</volume><issue>18</issue><spage>3719</spage><epage>3726</epage><pages>3719-3726</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>A mutant of
Escherchia coli enterotoxin induces specific Thl-type T cells to varicella-zoster vaccine. The mutant increased IL-12p40, TNFα and nitric oxide production by IFNγ-stimulated bone marrow macrophages but cholera toxin did not. Anti-TNFα antibodies blocked its stimulation of IL-12p40 production but iNOS inhibitor did not. IL-12p40 and IL-12p35 production was stimulated at the level of mRNA formation by the mutant. Cholera toxin suppressed IL-12β1 expression by spleen T cells stimulated with anti-CD3 antibodies but the mutant did not. These findings indicate that the mutant may induce Thl-type response to the vaccine through its IL-12 and TNFα induction by macrophages.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.vaccine.2005.07.010</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2006-05, Vol.24 (18), p.3719-3726 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17168124 |
| source | ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Enterotoxigenic Escherichia coli Escherichia coli Heat-labile enterotoxin IL-12 Macrophage Mutant TNFα Varicella-zoster virus |
| title | A mutant of Escherichia coli enterotoxin inducing a specific Thl-type of T cells to varicella-zoster vaccine enhances the production of IL-12 by IFNγ-stimulated macrophages |
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