Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats
Cellular regeneration and tissue repair greatly influence the outcome of acute carbon tetrachloride (CCl 4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague–Dawley (SD) rats following an acute CCl 4 exposure (0....
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| Veröffentlicht in: | Toxicology (Amsterdam) 1998-09, Vol.130 (2), p.95-105 |
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| creator | Moghaddam, Abdollah P. Eggers, Jeffrey S. Calabrese, Edward J. |
| description | Cellular regeneration and tissue repair greatly influence the outcome of acute carbon tetrachloride (CCl
4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague–Dawley (SD) rats following an acute CCl
4 exposure (0.8 ml/kg, i.p.). In female rats, hepatic damage peaked at 24 h following the treatment and was ∼2.5-fold (AST 2.7-fold, ALT 2.3 fold) greater than the damage observed in male rats. The hepatic damage in male rats appeared to peak by 3 h post-exposure and did not significantly change through the 36-h time-point. The activity of cytochrome P 4502E1 was 20% greater in male rats and did not correlate with the magnitude of hepatic damage. Morphometric analysis of cell cycle indices revealed that cellular regeneration was significantly greater in female rats as compared to male rats at 48 h and corresponded proportionally to the extent of liver damage. This study demonstrated that female SD rats respond more severely to acute CCl
4 hepatotoxicity than male SD rats and the extent of tissue repair and cellular regeneration was greater in female rats. Furthermore, our results suggest that tissue repair is unlikely to result in accounting for the different responses exhibited by male and female SD rats to CCl
4 hepatotoxicity. |
| doi_str_mv | 10.1016/S0300-483X(98)00095-X |
| format | Article |
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4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague–Dawley (SD) rats following an acute CCl
4 exposure (0.8 ml/kg, i.p.). In female rats, hepatic damage peaked at 24 h following the treatment and was ∼2.5-fold (AST 2.7-fold, ALT 2.3 fold) greater than the damage observed in male rats. The hepatic damage in male rats appeared to peak by 3 h post-exposure and did not significantly change through the 36-h time-point. The activity of cytochrome P 4502E1 was 20% greater in male rats and did not correlate with the magnitude of hepatic damage. Morphometric analysis of cell cycle indices revealed that cellular regeneration was significantly greater in female rats as compared to male rats at 48 h and corresponded proportionally to the extent of liver damage. This study demonstrated that female SD rats respond more severely to acute CCl
4 hepatotoxicity than male SD rats and the extent of tissue repair and cellular regeneration was greater in female rats. Furthermore, our results suggest that tissue repair is unlikely to result in accounting for the different responses exhibited by male and female SD rats to CCl
4 hepatotoxicity.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(98)00095-X</identifier><identifier>PMID: 9865477</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Alanine Transaminase - blood ; Animals ; Aspartate Aminotransferases - blood ; Biological and medical sciences ; Blood Glucose ; Carbon Tetrachloride - toxicity ; CCl4 ; Cell Count ; Cell Cycle - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cytochrome P-450 CYP2E1 - metabolism ; Female ; L-Lactate Dehydrogenase - blood ; Liver ; Liver - drug effects ; Liver - enzymology ; Liver - physiopathology ; Liver Regeneration - physiology ; Male ; Medical sciences ; Necrosis ; Nutrition ; Proliferating Cell Nuclear Antigen - metabolism ; Rats ; Rats, Sprague-Dawley ; Repair ; Sex ; Sex Characteristics ; Solvents ; Time Factors ; Toxicology ; Triglycerides - blood</subject><ispartof>Toxicology (Amsterdam), 1998-09, Vol.130 (2), p.95-105</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d3f14af8022c1887eec88744f476acb7f28d1366ad7ff09b83529d9a21fe3e4c3</citedby><cites>FETCH-LOGICAL-c451t-d3f14af8022c1887eec88744f476acb7f28d1366ad7ff09b83529d9a21fe3e4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0300-483X(98)00095-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1641847$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9865477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moghaddam, Abdollah P.</creatorcontrib><creatorcontrib>Eggers, Jeffrey S.</creatorcontrib><creatorcontrib>Calabrese, Edward J.</creatorcontrib><title>Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Cellular regeneration and tissue repair greatly influence the outcome of acute carbon tetrachloride (CCl
4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague–Dawley (SD) rats following an acute CCl
4 exposure (0.8 ml/kg, i.p.). In female rats, hepatic damage peaked at 24 h following the treatment and was ∼2.5-fold (AST 2.7-fold, ALT 2.3 fold) greater than the damage observed in male rats. The hepatic damage in male rats appeared to peak by 3 h post-exposure and did not significantly change through the 36-h time-point. The activity of cytochrome P 4502E1 was 20% greater in male rats and did not correlate with the magnitude of hepatic damage. Morphometric analysis of cell cycle indices revealed that cellular regeneration was significantly greater in female rats as compared to male rats at 48 h and corresponded proportionally to the extent of liver damage. This study demonstrated that female SD rats respond more severely to acute CCl
4 hepatotoxicity than male SD rats and the extent of tissue repair and cellular regeneration was greater in female rats. Furthermore, our results suggest that tissue repair is unlikely to result in accounting for the different responses exhibited by male and female SD rats to CCl
4 hepatotoxicity.</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>CCl4</subject><subject>Cell Count</subject><subject>Cell Cycle - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cytochrome P-450 CYP2E1 - metabolism</subject><subject>Female</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - physiopathology</subject><subject>Liver Regeneration - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Nutrition</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Repair</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Solvents</subject><subject>Time Factors</subject><subject>Toxicology</subject><subject>Triglycerides - blood</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EKkvhESr5gBAcAnbsOM4JoVL-SJU4FKS9WbP2uBh5k8V22u6NQ9-gb8iTkOyuyrEXj6X5fmNrPkJOOHvLGVfvLphgrJJaLF93-g1jrGuq5SOy4LrtKsF185gs7pGn5FnOvyaoFlIdkaNOq0a27YLcnl1BHKGEoaeDpxlvqAveY8LeIg09LSHnEWnCDYRE_RDjcB36Swp2LEgtpNWULFgS2J9xSMEhLcNNsKFs5_gaIlLoHfW4u15sElyO-PfP3Ue4jrilCUp-Tp54iBlfHOox-fHp7Pvpl-r82-evpx_OKysbXionPJfgNatry7VuEe10Sullq8CuWl9rx4VS4FrvWbfSoqk710HNPQqUVhyTV_u5mzT8HjEXsw7ZYozQ4zBmw1uuWiXUw6BsmJCSTWCzB20ack7ozSaFNaSt4czMmsxOk5kdmE6bnSaznHInhwfG1RrdfergZeq_PPQhW4g-QW9D_j9cSa7ljL3fYzht7SpgMtmG2ZwLCW0xbggPfOQfIkSy9Q</recordid><startdate>19980915</startdate><enddate>19980915</enddate><creator>Moghaddam, Abdollah P.</creator><creator>Eggers, Jeffrey S.</creator><creator>Calabrese, Edward J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TK</scope><scope>7U7</scope></search><sort><creationdate>19980915</creationdate><title>Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats</title><author>Moghaddam, Abdollah P. ; Eggers, Jeffrey S. ; Calabrese, Edward J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d3f14af8022c1887eec88744f476acb7f28d1366ad7ff09b83529d9a21fe3e4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>CCl4</topic><topic>Cell Count</topic><topic>Cell Cycle - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cytochrome P-450 CYP2E1 - metabolism</topic><topic>Female</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - physiopathology</topic><topic>Liver Regeneration - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Nutrition</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Repair</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Solvents</topic><topic>Time Factors</topic><topic>Toxicology</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moghaddam, Abdollah P.</creatorcontrib><creatorcontrib>Eggers, Jeffrey S.</creatorcontrib><creatorcontrib>Calabrese, Edward J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moghaddam, Abdollah P.</au><au>Eggers, Jeffrey S.</au><au>Calabrese, Edward J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>1998-09-15</date><risdate>1998</risdate><volume>130</volume><issue>2</issue><spage>95</spage><epage>105</epage><pages>95-105</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>Cellular regeneration and tissue repair greatly influence the outcome of acute carbon tetrachloride (CCl
4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague–Dawley (SD) rats following an acute CCl
4 exposure (0.8 ml/kg, i.p.). In female rats, hepatic damage peaked at 24 h following the treatment and was ∼2.5-fold (AST 2.7-fold, ALT 2.3 fold) greater than the damage observed in male rats. The hepatic damage in male rats appeared to peak by 3 h post-exposure and did not significantly change through the 36-h time-point. The activity of cytochrome P 4502E1 was 20% greater in male rats and did not correlate with the magnitude of hepatic damage. Morphometric analysis of cell cycle indices revealed that cellular regeneration was significantly greater in female rats as compared to male rats at 48 h and corresponded proportionally to the extent of liver damage. This study demonstrated that female SD rats respond more severely to acute CCl
4 hepatotoxicity than male SD rats and the extent of tissue repair and cellular regeneration was greater in female rats. Furthermore, our results suggest that tissue repair is unlikely to result in accounting for the different responses exhibited by male and female SD rats to CCl
4 hepatotoxicity.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9865477</pmid><doi>10.1016/S0300-483X(98)00095-X</doi><tpages>11</tpages></addata></record> |
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| subjects | Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Biological and medical sciences Blood Glucose Carbon Tetrachloride - toxicity CCl4 Cell Count Cell Cycle - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP2E1 - metabolism Female L-Lactate Dehydrogenase - blood Liver Liver - drug effects Liver - enzymology Liver - physiopathology Liver Regeneration - physiology Male Medical sciences Necrosis Nutrition Proliferating Cell Nuclear Antigen - metabolism Rats Rats, Sprague-Dawley Repair Sex Sex Characteristics Solvents Time Factors Toxicology Triglycerides - blood |
| title | Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats |
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