Pseudomonas aeruginosa Killing of Caenorhabditis elegans Used to Identify P. aeruginosa Virulence Factors

We reported recently that the human opportunistic pathogen Pseudomonas aeruginosa strain PA14 kills Caenorhabditis elegans and that many P. aeruginosa virulence factors (genes) required for maximum virulence in mouse pathogenicity are also required for maximum killing of C. elegans. Here we report t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-03, Vol.96 (5), p.2408-2413
Hauptverfasser:	Tan, Man-Wah, Rahme, Laurence G., Sternberg, Jeffrey A., Tompkins, Ronald G., Ausubel, Frederick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabidopsis - microbiology Azotobacter vinelandii - genetics Bacteria Bacterial Proteins - genetics Base Sequence Biological Sciences Caenorhabditis elegans Caenorhabditis elegans - microbiology DNA Primers DNA Transposable Elements DNA-Binding Proteins - genetics Escherichia coli - genetics Genes Genes, Regulator Genetic Complementation Test Genetic screening Humans Mammals Mice Microbiology Molecular Sequence Data Mutagenesis, Insertional Neisseria gonorrhoeae - genetics Nematodes Pathogenesis Pathogens Phenotypes Plasmids Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - physiopathology Trans-Activators - genetics Transcription Factors - genetics Transcriptional regulatory elements Virulence Virulence - genetics Virulence factors Viruses Worms
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