Ammonia affects the activity and expression of soluble and particulate GC in cultured rat astrocytes

Neurotoxic effects of ammonia are mediated by increased accumulation of nitric oxide (NO), which combines with free radicals to form a highly toxic compound, peroxynitrite. Previous experiments in vivo and in vitro have suggested that this phenomenon engages neuron-derived NO and is coupled to chang...

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Veröffentlicht in:	Neurochemistry international 2006-05, Vol.48 (6), p.553-558
Hauptverfasser:	Konopacka, Agnieszka, Fręśko, Inez, Piaskowski, Sylwester, Albrecht, Jan, Zielińska, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Ammonia Ammonia - metabolism Ammonium Chloride - toxicity Animals Astrocytes Astrocytes - drug effects Astrocytes - enzymology Astrocytes - metabolism Biological and medical sciences Cells, Cultured Cerebral Cortex - cytology Cyclic GMP - biosynthesis Fundamental and applied biological sciences. Psychology Guanylate Cyclase - biosynthesis Guanylate Cyclase - genetics Hyperammonemia - enzymology Hyperammonemia - metabolism Neurons - enzymology Neurons - metabolism Particulate guanylate cyclase Protein Subunits - biosynthesis Protein Subunits - genetics Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - biosynthesis Receptors, Cytoplasmic and Nuclear - genetics RNA, Messenger - biosynthesis Soluble guanylate cyclase Soluble Guanylyl Cyclase Vertebrates: nervous system and sense organs
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