Evaluation of heart involvement in calpainopathy (LGMD2A) using cardiovascular magnetic resonance
ABSTRACT Introduction Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim of this study was to investigate cardiac involvement in calpainopathy (LGMD2A). Methods Cardiovascular evaluation was performed in 10 patients with genetically verified LGMD2A by echoc...
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| Veröffentlicht in: | Muscle & nerve 2015-10, Vol.52 (4), p.661-663 |
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| container_title | Muscle & nerve |
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| creator | Quick, Silvio Schaefer, Jochen Waessnig, Nadine Schultheiss, Thorsten Reuner, Ulrike Schoen, Steffen Reichmann, Heinz Strasser, Ruth Speiser, Uwe |
| description | ABSTRACT
Introduction
Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim of this study was to investigate cardiac involvement in calpainopathy (LGMD2A).
Methods
Cardiovascular evaluation was performed in 10 patients with genetically verified LGMD2A by echocardiography, 3 Tesla ‐ cardiovascular magnetic resonance, 24‐h electrocardiography recordings with heart rate variability (HRV) analysis, and 24‐h blood pressure recordings.
Results
No patient with calpainopathy showed impairment of left or right ventricular function. One patient had a small amount (2% of left ventricle mass) of late gadolinium enhancement. HRV analysis revealed no significant difference compared with external reference data.
Conclusions
The main finding of this study is the lack of cardiac involvement in patients with calpainopathy. Cardiac involvement was not found, even in individuals with advanced age and greater disease severity. Furthermore, we did not observe an overall reduction of cardiac autonomic regulation in calpainopathy. Muscle Nerve 52: 661–663, 2015 |
| doi_str_mv | 10.1002/mus.24717 |
| format | Article |
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Introduction
Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim of this study was to investigate cardiac involvement in calpainopathy (LGMD2A).
Methods
Cardiovascular evaluation was performed in 10 patients with genetically verified LGMD2A by echocardiography, 3 Tesla ‐ cardiovascular magnetic resonance, 24‐h electrocardiography recordings with heart rate variability (HRV) analysis, and 24‐h blood pressure recordings.
Results
No patient with calpainopathy showed impairment of left or right ventricular function. One patient had a small amount (2% of left ventricle mass) of late gadolinium enhancement. HRV analysis revealed no significant difference compared with external reference data.
Conclusions
The main finding of this study is the lack of cardiac involvement in patients with calpainopathy. Cardiac involvement was not found, even in individuals with advanced age and greater disease severity. Furthermore, we did not observe an overall reduction of cardiac autonomic regulation in calpainopathy. Muscle Nerve 52: 661–663, 2015</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.24717</identifier><identifier>PMID: 26032656</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Blood Pressure ; calpainopathy ; cardiac magnetic resonance imaging ; Cardiovascular System - physiopathology ; Echocardiography ; Female ; Heart - physiopathology ; Heart Rate - physiology ; heart rate variability ; Humans ; Imaging, Three-Dimensional ; LGMD2A ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Muscular Dystrophies, Limb-Girdle - pathology ; Muscular Dystrophies, Limb-Girdle - physiopathology ; muscular dystrophy ; Young Adult</subject><ispartof>Muscle & nerve, 2015-10, Vol.52 (4), p.661-663</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4337-d9867bcca9db484f58341f1e7994a26d4ef8985147b315e7fe805832ac4f98393</citedby><cites>FETCH-LOGICAL-c4337-d9867bcca9db484f58341f1e7994a26d4ef8985147b315e7fe805832ac4f98393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.24717$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.24717$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26032656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quick, Silvio</creatorcontrib><creatorcontrib>Schaefer, Jochen</creatorcontrib><creatorcontrib>Waessnig, Nadine</creatorcontrib><creatorcontrib>Schultheiss, Thorsten</creatorcontrib><creatorcontrib>Reuner, Ulrike</creatorcontrib><creatorcontrib>Schoen, Steffen</creatorcontrib><creatorcontrib>Reichmann, Heinz</creatorcontrib><creatorcontrib>Strasser, Ruth</creatorcontrib><creatorcontrib>Speiser, Uwe</creatorcontrib><title>Evaluation of heart involvement in calpainopathy (LGMD2A) using cardiovascular magnetic resonance</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>ABSTRACT
Introduction
Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim of this study was to investigate cardiac involvement in calpainopathy (LGMD2A).
Methods
Cardiovascular evaluation was performed in 10 patients with genetically verified LGMD2A by echocardiography, 3 Tesla ‐ cardiovascular magnetic resonance, 24‐h electrocardiography recordings with heart rate variability (HRV) analysis, and 24‐h blood pressure recordings.
Results
No patient with calpainopathy showed impairment of left or right ventricular function. One patient had a small amount (2% of left ventricle mass) of late gadolinium enhancement. HRV analysis revealed no significant difference compared with external reference data.
Conclusions
The main finding of this study is the lack of cardiac involvement in patients with calpainopathy. Cardiac involvement was not found, even in individuals with advanced age and greater disease severity. Furthermore, we did not observe an overall reduction of cardiac autonomic regulation in calpainopathy. Muscle Nerve 52: 661–663, 2015</description><subject>Adult</subject><subject>Blood Pressure</subject><subject>calpainopathy</subject><subject>cardiac magnetic resonance imaging</subject><subject>Cardiovascular System - physiopathology</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Heart Rate - physiology</subject><subject>heart rate variability</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>LGMD2A</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscular Dystrophies, Limb-Girdle - pathology</subject><subject>Muscular Dystrophies, Limb-Girdle - physiopathology</subject><subject>muscular dystrophy</subject><subject>Young Adult</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFO3DAQhi3UCraUAy9Q5QiHgB07sX1ECyyVFipBUSsu1qwzAbeJvdjJln37ZrvAracZab7_1-gj5JDRE0ZpcdoN6aQQkskdMmFUy1yUWn0gE8qEyiuuf-6RTyn9opQyVcldsldUlBdVWU0IXKygHaB3wWehyZ4QYp85vwrtCjv0mz2z0C7B-bCE_mmdHc1n1-fF2XE2JOcfx2OsXVhBskMLMevg0WPvbBYxBQ_e4mfysYE24cHr3Cf3lxffp1f5_Nvs6_RsnlvBucxrPb62sBZ0vRBKNKXigjUMpdYCiqoW2CitSibkgrMSZYOKjkwBVjRacc33ydG2dxnD84CpN51LFtsWPIYhGSZZVZRCqg16vEVtDClFbMwyug7i2jBqNkbNaNT8MzqyX15rh0WH9Tv5pnAETrfAH9fi-v9N5vr-7q0y3yZc6vHlPQHxt6kkl6X5cTMzD7f8RqmpMg_8L9iyj2c</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Quick, Silvio</creator><creator>Schaefer, Jochen</creator><creator>Waessnig, Nadine</creator><creator>Schultheiss, Thorsten</creator><creator>Reuner, Ulrike</creator><creator>Schoen, Steffen</creator><creator>Reichmann, Heinz</creator><creator>Strasser, Ruth</creator><creator>Speiser, Uwe</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Evaluation of heart involvement in calpainopathy (LGMD2A) using cardiovascular magnetic resonance</title><author>Quick, Silvio ; Schaefer, Jochen ; Waessnig, Nadine ; Schultheiss, Thorsten ; Reuner, Ulrike ; Schoen, Steffen ; Reichmann, Heinz ; Strasser, Ruth ; Speiser, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4337-d9867bcca9db484f58341f1e7994a26d4ef8985147b315e7fe805832ac4f98393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood Pressure</topic><topic>calpainopathy</topic><topic>cardiac magnetic resonance imaging</topic><topic>Cardiovascular System - physiopathology</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Heart Rate - physiology</topic><topic>heart rate variability</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>LGMD2A</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscular Dystrophies, Limb-Girdle - pathology</topic><topic>Muscular Dystrophies, Limb-Girdle - physiopathology</topic><topic>muscular dystrophy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quick, Silvio</creatorcontrib><creatorcontrib>Schaefer, Jochen</creatorcontrib><creatorcontrib>Waessnig, Nadine</creatorcontrib><creatorcontrib>Schultheiss, Thorsten</creatorcontrib><creatorcontrib>Reuner, Ulrike</creatorcontrib><creatorcontrib>Schoen, Steffen</creatorcontrib><creatorcontrib>Reichmann, Heinz</creatorcontrib><creatorcontrib>Strasser, Ruth</creatorcontrib><creatorcontrib>Speiser, Uwe</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quick, Silvio</au><au>Schaefer, Jochen</au><au>Waessnig, Nadine</au><au>Schultheiss, Thorsten</au><au>Reuner, Ulrike</au><au>Schoen, Steffen</au><au>Reichmann, Heinz</au><au>Strasser, Ruth</au><au>Speiser, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of heart involvement in calpainopathy (LGMD2A) using cardiovascular magnetic resonance</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2015-10</date><risdate>2015</risdate><volume>52</volume><issue>4</issue><spage>661</spage><epage>663</epage><pages>661-663</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>ABSTRACT
Introduction
Cardiac dysfunction occurs in several forms of limb girdle muscular dystrophy (LGMD). The aim of this study was to investigate cardiac involvement in calpainopathy (LGMD2A).
Methods
Cardiovascular evaluation was performed in 10 patients with genetically verified LGMD2A by echocardiography, 3 Tesla ‐ cardiovascular magnetic resonance, 24‐h electrocardiography recordings with heart rate variability (HRV) analysis, and 24‐h blood pressure recordings.
Results
No patient with calpainopathy showed impairment of left or right ventricular function. One patient had a small amount (2% of left ventricle mass) of late gadolinium enhancement. HRV analysis revealed no significant difference compared with external reference data.
Conclusions
The main finding of this study is the lack of cardiac involvement in patients with calpainopathy. Cardiac involvement was not found, even in individuals with advanced age and greater disease severity. Furthermore, we did not observe an overall reduction of cardiac autonomic regulation in calpainopathy. Muscle Nerve 52: 661–663, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26032656</pmid><doi>10.1002/mus.24717</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Blood Pressure calpainopathy cardiac magnetic resonance imaging Cardiovascular System - physiopathology Echocardiography Female Heart - physiopathology Heart Rate - physiology heart rate variability Humans Imaging, Three-Dimensional LGMD2A Magnetic Resonance Spectroscopy Male Middle Aged Muscular Dystrophies, Limb-Girdle - pathology Muscular Dystrophies, Limb-Girdle - physiopathology muscular dystrophy Young Adult |
| title | Evaluation of heart involvement in calpainopathy (LGMD2A) using cardiovascular magnetic resonance |
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