A Gene Upregulated in the Acoustically Damaged Chick Basilar Papilla Encodes a Novel WD40 Repeat Protein
The chickWDR1gene is expressed at higher levels in the chick basilar papilla after acoustic overstimulation. The 3.3-kbWDR1cDNA encodes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein–protein interactions. The predicted WDR1 protein has high sequence identity to WD40...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1999-02, Vol.56 (1), p.59-69 |
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| creator | Adler, Henry J. Winnicki, Robert S. Gong, Tzy-Wen L. Lomax, Margaret I. |
| description | The chickWDR1gene is expressed at higher levels in the chick basilar papilla after acoustic overstimulation. The 3.3-kbWDR1cDNA encodes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein–protein interactions. The predicted WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cerevisiae), two slime molds (Dictyostelium discoideumandPhysarum polycephalum), and the roundworm (Caenorhabditis elegans). The yeast andP. polycephalumproteins bind actin, suggesting that the novel chick protein may be an actin-binding protein. Sequence database comparisons identified mouse and human cDNAs with high sequence identity to the chickWDR1cDNA. The mouse Wdr1 and human WDR1 proteins showed 95% sequence identity to each other and 86% identity to the chick WDR1 protein. Northern blot analysis of total RNA from the chick basilar papilla after noise trauma revealed increased levels of a 3.1-kb transcript in the lesioned area. TheWDR1gene was mapped to human chromosome 4, between 22 and 24 cM from the telomere of 4p. |
| doi_str_mv | 10.1006/geno.1998.5672 |
| format | Article |
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The 3.3-kbWDR1cDNA encodes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein–protein interactions. The predicted WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cerevisiae), two slime molds (Dictyostelium discoideumandPhysarum polycephalum), and the roundworm (Caenorhabditis elegans). The yeast andP. polycephalumproteins bind actin, suggesting that the novel chick protein may be an actin-binding protein. Sequence database comparisons identified mouse and human cDNAs with high sequence identity to the chickWDR1cDNA. The mouse Wdr1 and human WDR1 proteins showed 95% sequence identity to each other and 86% identity to the chick WDR1 protein. Northern blot analysis of total RNA from the chick basilar papilla after noise trauma revealed increased levels of a 3.1-kb transcript in the lesioned area. TheWDR1gene was mapped to human chromosome 4, between 22 and 24 cM from the telomere of 4p.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1998.5672</identifier><identifier>PMID: 10036186</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>actin ; actin binding proteins ; Actins - genetics ; Amino Acid Sequence ; amino acid sequences ; Animals ; Base Sequence ; Basilar Membrane - metabolism ; binding proteins ; Biological and medical sciences ; Caenorhabditis elegans ; chickens ; Chickens - genetics ; Chickens - physiology ; chromosome mapping ; Chromosomes, Human, Pair 4 - genetics ; complementary DNA ; Dictyostelium discoideum ; ears ; Fundamental and applied biological sciences. Psychology ; genbank/af020054 ; genbank/af020055 ; genbank/af020056 ; genbank/af020260 ; Gene Expression ; gene location ; Genes. Genome ; genetic regulation ; Hearing Loss, Noise-Induced - genetics ; Humans ; messenger RNA ; Mice ; Microfilament Proteins - genetics ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; noise trauma ; Nucleic Acid Hybridization ; nucleotide sequences ; Physarum polycephalum ; Restriction Mapping ; Saccharomyces cerevisiae ; Sequence Alignment ; Sequence Homology, Amino Acid ; sounds ; species differences ; structural genes ; wdr1 gene</subject><ispartof>Genomics (San Diego, Calif.), 1999-02, Vol.56 (1), p.59-69</ispartof><rights>1999 Academic Press</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-bf25472ecba6a1afd3437e10c65cf17eba56282037b2d8861d597e0c88f6dddf3</citedby><cites>FETCH-LOGICAL-c424t-bf25472ecba6a1afd3437e10c65cf17eba56282037b2d8861d597e0c88f6dddf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1998.5672$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1709376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10036186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adler, Henry J.</creatorcontrib><creatorcontrib>Winnicki, Robert S.</creatorcontrib><creatorcontrib>Gong, Tzy-Wen L.</creatorcontrib><creatorcontrib>Lomax, Margaret I.</creatorcontrib><title>A Gene Upregulated in the Acoustically Damaged Chick Basilar Papilla Encodes a Novel WD40 Repeat Protein</title><title>Genomics (San Diego, Calif.)</title><addtitle>Genomics</addtitle><description>The chickWDR1gene is expressed at higher levels in the chick basilar papilla after acoustic overstimulation. The 3.3-kbWDR1cDNA encodes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein–protein interactions. The predicted WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cerevisiae), two slime molds (Dictyostelium discoideumandPhysarum polycephalum), and the roundworm (Caenorhabditis elegans). The yeast andP. polycephalumproteins bind actin, suggesting that the novel chick protein may be an actin-binding protein. Sequence database comparisons identified mouse and human cDNAs with high sequence identity to the chickWDR1cDNA. The mouse Wdr1 and human WDR1 proteins showed 95% sequence identity to each other and 86% identity to the chick WDR1 protein. Northern blot analysis of total RNA from the chick basilar papilla after noise trauma revealed increased levels of a 3.1-kb transcript in the lesioned area. TheWDR1gene was mapped to human chromosome 4, between 22 and 24 cM from the telomere of 4p.</description><subject>actin</subject><subject>actin binding proteins</subject><subject>Actins - genetics</subject><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Basilar Membrane - metabolism</subject><subject>binding proteins</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis elegans</subject><subject>chickens</subject><subject>Chickens - genetics</subject><subject>Chickens - physiology</subject><subject>chromosome mapping</subject><subject>Chromosomes, Human, Pair 4 - genetics</subject><subject>complementary DNA</subject><subject>Dictyostelium discoideum</subject><subject>ears</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genbank/af020054</subject><subject>genbank/af020055</subject><subject>genbank/af020056</subject><subject>genbank/af020260</subject><subject>Gene Expression</subject><subject>gene location</subject><subject>Genes. Genome</subject><subject>genetic regulation</subject><subject>Hearing Loss, Noise-Induced - genetics</subject><subject>Humans</subject><subject>messenger RNA</subject><subject>Mice</subject><subject>Microfilament Proteins - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>noise trauma</subject><subject>Nucleic Acid Hybridization</subject><subject>nucleotide sequences</subject><subject>Physarum polycephalum</subject><subject>Restriction Mapping</subject><subject>Saccharomyces cerevisiae</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>sounds</subject><subject>species differences</subject><subject>structural genes</subject><subject>wdr1 gene</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EGP1CAUwHFiNO64evWoHIy3jkBboMdxdl1NNrpRJx7JK7zOoJ1SobPJfntpOolePHHgB3nvT8hLztacMfluj0NY86bR61oq8YisONNNoWUlH5MV01oXqq7KC_IspZ-MsabU4im5yE9LybVckcOG3uCAdDdG3J96mNBRP9DpgHRjwylN3kLfP9ArOMI-320P3v6i7yH5HiK9g9H3PdDrwQaHiQL9HO6xpz-uKka_4ogw0bsYJvTDc_Kkgz7hi_N5SXYfrr9vPxa3X24-bTe3ha1ENRVtJ-pKCbQtSODQubIqFXJmZW07rrCFWgotWKla4bSW3NWNQma17qRzrisvydvl3zGG3ydMkzn6ZDFPOWDex3DF8-ZaZbheoI0hpYidGaM_QnwwnJm5rZnbmrmtmdvmB6_OP5_aI7p_-BIzgzdnAClX6yIM1qe_TuX8amavF9ZBMLCPmey-CcZLJnQjWVVnoReBOdS9x2iS9ThYdD6inYwL_n9D_gHDa53A</recordid><startdate>19990215</startdate><enddate>19990215</enddate><creator>Adler, Henry J.</creator><creator>Winnicki, Robert S.</creator><creator>Gong, Tzy-Wen L.</creator><creator>Lomax, Margaret I.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19990215</creationdate><title>A Gene Upregulated in the Acoustically Damaged Chick Basilar Papilla Encodes a Novel WD40 Repeat Protein</title><author>Adler, Henry J. ; Winnicki, Robert S. ; Gong, Tzy-Wen L. ; Lomax, Margaret I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-bf25472ecba6a1afd3437e10c65cf17eba56282037b2d8861d597e0c88f6dddf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>actin</topic><topic>actin binding proteins</topic><topic>Actins - genetics</topic><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Basilar Membrane - metabolism</topic><topic>binding proteins</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis elegans</topic><topic>chickens</topic><topic>Chickens - genetics</topic><topic>Chickens - physiology</topic><topic>chromosome mapping</topic><topic>Chromosomes, Human, Pair 4 - genetics</topic><topic>complementary DNA</topic><topic>Dictyostelium discoideum</topic><topic>ears</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genbank/af020054</topic><topic>genbank/af020055</topic><topic>genbank/af020056</topic><topic>genbank/af020260</topic><topic>Gene Expression</topic><topic>gene location</topic><topic>Genes. Genome</topic><topic>genetic regulation</topic><topic>Hearing Loss, Noise-Induced - genetics</topic><topic>Humans</topic><topic>messenger RNA</topic><topic>Mice</topic><topic>Microfilament Proteins - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>noise trauma</topic><topic>Nucleic Acid Hybridization</topic><topic>nucleotide sequences</topic><topic>Physarum polycephalum</topic><topic>Restriction Mapping</topic><topic>Saccharomyces cerevisiae</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>sounds</topic><topic>species differences</topic><topic>structural genes</topic><topic>wdr1 gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adler, Henry J.</creatorcontrib><creatorcontrib>Winnicki, Robert S.</creatorcontrib><creatorcontrib>Gong, Tzy-Wen L.</creatorcontrib><creatorcontrib>Lomax, Margaret I.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genomics (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adler, Henry J.</au><au>Winnicki, Robert S.</au><au>Gong, Tzy-Wen L.</au><au>Lomax, Margaret I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Gene Upregulated in the Acoustically Damaged Chick Basilar Papilla Encodes a Novel WD40 Repeat Protein</atitle><jtitle>Genomics (San Diego, Calif.)</jtitle><addtitle>Genomics</addtitle><date>1999-02-15</date><risdate>1999</risdate><volume>56</volume><issue>1</issue><spage>59</spage><epage>69</epage><pages>59-69</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>The chickWDR1gene is expressed at higher levels in the chick basilar papilla after acoustic overstimulation. The 3.3-kbWDR1cDNA encodes a novel 67-kDa protein containing nine WD40 repeats, motifs that mediate protein–protein interactions. The predicted WDR1 protein has high sequence identity to WD40-repeat proteins in budding yeast (Saccharomyces cerevisiae), two slime molds (Dictyostelium discoideumandPhysarum polycephalum), and the roundworm (Caenorhabditis elegans). The yeast andP. polycephalumproteins bind actin, suggesting that the novel chick protein may be an actin-binding protein. Sequence database comparisons identified mouse and human cDNAs with high sequence identity to the chickWDR1cDNA. The mouse Wdr1 and human WDR1 proteins showed 95% sequence identity to each other and 86% identity to the chick WDR1 protein. Northern blot analysis of total RNA from the chick basilar papilla after noise trauma revealed increased levels of a 3.1-kb transcript in the lesioned area. TheWDR1gene was mapped to human chromosome 4, between 22 and 24 cM from the telomere of 4p.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>10036186</pmid><doi>10.1006/geno.1998.5672</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0888-7543 |
| ispartof | Genomics (San Diego, Calif.), 1999-02, Vol.56 (1), p.59-69 |
| issn | 0888-7543 1089-8646 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | actin actin binding proteins Actins - genetics Amino Acid Sequence amino acid sequences Animals Base Sequence Basilar Membrane - metabolism binding proteins Biological and medical sciences Caenorhabditis elegans chickens Chickens - genetics Chickens - physiology chromosome mapping Chromosomes, Human, Pair 4 - genetics complementary DNA Dictyostelium discoideum ears Fundamental and applied biological sciences. Psychology genbank/af020054 genbank/af020055 genbank/af020056 genbank/af020260 Gene Expression gene location Genes. Genome genetic regulation Hearing Loss, Noise-Induced - genetics Humans messenger RNA Mice Microfilament Proteins - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data noise trauma Nucleic Acid Hybridization nucleotide sequences Physarum polycephalum Restriction Mapping Saccharomyces cerevisiae Sequence Alignment Sequence Homology, Amino Acid sounds species differences structural genes wdr1 gene |
| title | A Gene Upregulated in the Acoustically Damaged Chick Basilar Papilla Encodes a Novel WD40 Repeat Protein |
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