Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action

PSILOCYBIN, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsy...

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Veröffentlicht in:	Neuroreport 1998-12, Vol.9 (17), p.3897-3902
Hauptverfasser:	Vollenweider, Franz X, Vollenweider-Scherpenhuyzen, Margreet F. I, Bäbler, Andreas, Vogel, Helen, Hell, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Dose-Response Relationship, Drug Female Hallucinogens - adverse effects Humans Ketanserin - pharmacology Male Medical sciences Neuropsychological Tests Psilocybin - adverse effects Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopathology. Psychiatry Psychoses Reaction Time - drug effects Reference Values Schizophrenia Schizophrenia - chemically induced Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - adverse effects
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