Early anti‐nucleosome autoantibodies from a single MRL +/+ mouse: fine specificity, V gene structure and pathogenicity

In systemic lupus erythematosus, the nucleosome assumes a central role in the autoimmune response to self antigens. To gain insight into the etiology and pathogenesis of anti‐nucleosome antibodies (Ab), we analyzed a panel of six IgG‐secreting hybridomas derived from a single young MRL +/+ mouse at...

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