Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway

BACKGROUND—Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS—In wild-type mice, Sirt...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2015-09, Vol.132 (12), p.1081-1093
Hauptverfasser:	Araki, Satoshi, Izumiya, Yasuhiro, Rokutanda, Taku, Ianni, Alessandro, Hanatani, Shinsuke, Kimura, Yuichi, Onoue, Yoshiro, Senokuchi, Takafumi, Yoshizawa, Tatsuya, Yasuda, Osamu, Koitabashi, Norimichi, Kurabayashi, Masahiko, Braun, Thomas, Bober, Eva, Yamagata, Kazuya, Ogawa, Hisao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - drug effects Disease Models, Animal Fibroblasts - drug effects Fibroblasts - pathology Heart - physiology Hindlimb - blood supply In Vitro Techniques Ischemia - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Infarction - physiopathology Neovascularization, Physiologic - physiology Regeneration - physiology RNA, Small Interfering - pharmacology Signal Transduction - physiology Sirtuins - deficiency Sirtuins - genetics Sirtuins - physiology Transforming Growth Factor beta - physiology Wound Healing - physiology
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