IGFBP‐2 expression in a human cell line is associated with increased IGFBP‐3 proteolysis, decreased IGFBP‐1 expression and increased tumorigenicity

Insulin‐like growth factors (IGF‐I and ‐II) play an active role in cell proliferation. In biological fluids, they are non‐covalently bound to high‐affinity binding proteins (IGFBPs), at least 6 species of which have been identified to date, but with poorly defined functions. One of these IGFBPs, IGF...

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