Enantiospecific pharmacokinetics of isoxanthohumol and its metabolite 8-prenylnaringenin in the rat

Scope Isoxanthohumol (IX) is a bioactive dietary prenylflavanone found in hops (Humulus lupulus L.), beer and nutraceuticals. IX is formed in vivo by xanthohumol and is a prodrug of 8‐prenylnaringenin (8PN). IX and 8PN chirality has largely been ignored in the literature due to lack of enantiospecif...

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Veröffentlicht in:	Molecular nutrition & food research 2015-09, Vol.59 (9), p.1674-1689
Hauptverfasser:	Martinez, Stephanie E., Davies, Neal M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Administration, Oral Animals Biological Availability Chiral Circular Dichroism Dietary Supplements Flavanones - blood Flavanones - pharmacokinetics Flavanones - urine Flavonoids Glucuronides - blood Humulus - chemistry Isoxanthohumol LC-MS Male Pharmacokinetics Plant Extracts - blood Plant Extracts - pharmacokinetics Plant Extracts - urine Rats Rats, Sprague-Dawley Xanthones - blood Xanthones - pharmacokinetics Xanthones - urine
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