Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats

[Display omitted] •Pharmacokinetics of emodin and its glucuronidation were investigated by LC–MS/MS method.•The comparison of bioavailability and pharmacokinetics between emodin alone and in combination with piperine were carried out.•Piperine significantly improved the in vivo bioavailability of em...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2015-11, Vol.115, p.144-149
Hauptverfasser:	Di, Xin, Wang, Xin, Liu, Youping
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alkaloids - administration & dosage Alkaloids - pharmacology Animals Area Under Curve Benzodioxoles - administration & dosage Benzodioxoles - pharmacology Biological Availability Chromatography, High Pressure Liquid - methods Drug Interactions Emodin - administration & dosage Emodin - blood Emodin - pharmacokinetics Emodin Piperine UDP-glucuronosyltransferases (UGTs) Inhibition Female Glucuronides - metabolism Limit of Detection Linear Models Pharmacokinetics bioavailability Piperidines - administration & dosage Piperidines - pharmacology Polyunsaturated Alkamides - administration & dosage Polyunsaturated Alkamides - pharmacology Rats, Sprague-Dawley Reproducibility of Results Tandem Mass Spectrometry - methods
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