Carbon-Detected (15)N NMR Spin Relaxation of an Intrinsically Disordered Protein: FCP1 Dynamics Unbound and in Complex with RAP74

Intrinsically disordered proteins (IDPs) lack unique 3D structures under native conditions and as such exist as highly dynamic ensembles in solution. We present two (13)C-direct detection experiments for the measurement of (15)N NMR spin relaxation called the CON(T1)-IPAP and CON(T2)-IPAP that quant...

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Veröffentlicht in:	The journal of physical chemistry letters 2012-05, Vol.3 (10), p.1409-1413
Hauptverfasser:	Lawrence, Chad W, Showalter, Scott A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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