Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS
[Display omitted] A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang–huang–lian powder injecti...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2015-11, Vol.115, p.86-106 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Sun, Hongyang Liu, Meixian Lin, Zongtao Jiang, Haixiu Niu, Yanyan Wang, Hong Chen, Shizhong |
| description | [Display omitted]
A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang–huang–lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula. |
| doi_str_mv | 10.1016/j.jpba.2015.06.013 |
| format | Article |
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A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang–huang–lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2015.06.013</identifier><identifier>PMID: 26177215</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acids - analysis ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal - chemistry ; Flavonoids ; Flavonoids - analysis ; Glycosides - analysis ; HPLC-DAD-ESI-IT-TOF-MS ; Hydroxybenzoates - analysis ; Injections ; Iridoid glycosides ; Lignans - analysis ; Phenolic acids ; Phenylethanoid glycosides ; Powders ; Shuang–huang–lian powder injection ; Spectrometry, Mass, Electrospray Ionization</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2015-11, Vol.115, p.86-106</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6636223ced2a793205035a8b9e22e2f14dd226f2eb7bc46adb659d4e59abefe63</citedby><cites>FETCH-LOGICAL-c356t-6636223ced2a793205035a8b9e22e2f14dd226f2eb7bc46adb659d4e59abefe63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0731708515300352$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26177215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Hongyang</creatorcontrib><creatorcontrib>Liu, Meixian</creatorcontrib><creatorcontrib>Lin, Zongtao</creatorcontrib><creatorcontrib>Jiang, Haixiu</creatorcontrib><creatorcontrib>Niu, Yanyan</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Chen, Shizhong</creatorcontrib><title>Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>[Display omitted]
A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang–huang–lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula.</description><subject>Amino Acids - analysis</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Glycosides - analysis</subject><subject>HPLC-DAD-ESI-IT-TOF-MS</subject><subject>Hydroxybenzoates - analysis</subject><subject>Injections</subject><subject>Iridoid glycosides</subject><subject>Lignans - analysis</subject><subject>Phenolic acids</subject><subject>Phenylethanoid glycosides</subject><subject>Powders</subject><subject>Shuang–huang–lian powder injection</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0EotPCC7BAXrJx6p_YnkhsqmlLRxpUpBkkdpYT31BH-cNOirqDZ-gb8iR4Om2XXV3J_s6RzofQB0YzRpk6bbJmLG3GKZMZVRll4hVasKUWhKv8x2u0oFowoulSHqHjGBtKqWRF_hYdccW05kwu0N_V0I0BbqCP_hawd9BPvvaVnfzQ46HGjEvczW16tMEPc8TV0MfJT3MCI_Y93t7Mtv_578_902297fE4_HYQ0n8D1UNVeYevvm1W5PzsnFxs12S9I7vrS_J1-w69qW0b4f3jPUHfLy92qyuyuf6yXp1tSCWkmohSQnEuKnDc6kJwKqmQdlkWwDnwmuXOca5qDqUuq1xZVypZuBxkYUuoQYkT9OnQO4bh1wxxMp2PFbSt7SHtMkwzmSJcs4TyA1qFIcYAtRmD72y4M4yavXrTmL16s1dvqDJJfQp9fOyfyw7cc-TJdQI-HwBIK289BBMrD31a5EOSZNzgX-r_DwDZl2Y</recordid><startdate>20151110</startdate><enddate>20151110</enddate><creator>Sun, Hongyang</creator><creator>Liu, Meixian</creator><creator>Lin, Zongtao</creator><creator>Jiang, Haixiu</creator><creator>Niu, Yanyan</creator><creator>Wang, Hong</creator><creator>Chen, Shizhong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151110</creationdate><title>Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS</title><author>Sun, Hongyang ; Liu, Meixian ; Lin, Zongtao ; Jiang, Haixiu ; Niu, Yanyan ; Wang, Hong ; Chen, Shizhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6636223ced2a793205035a8b9e22e2f14dd226f2eb7bc46adb659d4e59abefe63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amino Acids - analysis</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Flavonoids</topic><topic>Flavonoids - analysis</topic><topic>Glycosides - analysis</topic><topic>HPLC-DAD-ESI-IT-TOF-MS</topic><topic>Hydroxybenzoates - analysis</topic><topic>Injections</topic><topic>Iridoid glycosides</topic><topic>Lignans - analysis</topic><topic>Phenolic acids</topic><topic>Phenylethanoid glycosides</topic><topic>Powders</topic><topic>Shuang–huang–lian powder injection</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Hongyang</creatorcontrib><creatorcontrib>Liu, Meixian</creatorcontrib><creatorcontrib>Lin, Zongtao</creatorcontrib><creatorcontrib>Jiang, Haixiu</creatorcontrib><creatorcontrib>Niu, Yanyan</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><creatorcontrib>Chen, Shizhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Hongyang</au><au>Liu, Meixian</au><au>Lin, Zongtao</au><au>Jiang, Haixiu</au><au>Niu, Yanyan</au><au>Wang, Hong</au><au>Chen, Shizhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2015-11-10</date><risdate>2015</risdate><volume>115</volume><spage>86</spage><epage>106</epage><pages>86-106</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><abstract>[Display omitted]
A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang–huang–lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>26177215</pmid><doi>10.1016/j.jpba.2015.06.013</doi><tpages>21</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2015-11, Vol.115, p.86-106 |
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| subjects | Amino Acids - analysis Chromatography, High Pressure Liquid Drugs, Chinese Herbal - chemistry Flavonoids Flavonoids - analysis Glycosides - analysis HPLC-DAD-ESI-IT-TOF-MS Hydroxybenzoates - analysis Injections Iridoid glycosides Lignans - analysis Phenolic acids Phenylethanoid glycosides Powders Shuang–huang–lian powder injection Spectrometry, Mass, Electrospray Ionization |
| title | Comprehensive identification of 125 multifarious constituents in Shuang–huang–lian powder injection by HPLC-DAD-ESI-IT-TOF-MS |
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