Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels
Background Diabetes induces bone alterations accompanied by altered cytokine expression patterns. These alterations lead to modified fracture healing, contributing to musculoskeletal fragility in the elderly. Aims We evaluated the inflammatory immune response in diabetic patients during fracture hea...
Gespeichert in:
| Veröffentlicht in: | Aging clinical and experimental research 2015-10, Vol.27 (Suppl 1), p.37-44 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 44 |
|---|---|
| container_issue | Suppl 1 |
| container_start_page | 37 |
| container_title | Aging clinical and experimental research |
| container_volume | 27 |
| creator | Liuni, Federico Maria Rugiero, Clelia Feola, Maurizio Rao, Cecilia Pistillo, Pietro Terracciano, Chiara Giganti, Maria Gabriella Tarantino, Umberto |
| description | Background
Diabetes induces bone alterations accompanied by altered cytokine expression patterns. These alterations lead to modified fracture healing, contributing to musculoskeletal fragility in the elderly.
Aims
We evaluated the inflammatory immune response in diabetic patients during fracture healing relative to clinical and radiographic assessments.
Methods
Fifty patients of both sexes with fragility fractures were studied: 30 diabetics (group A, mean age 73.4 ± 11.2 years) and 20 normoglycemic controls (group B, mean age 75.1 ± 16.9 years). Two subgroups comprised those with hip or wrist fragility fractures (25 and 16 patients, respectively). We evaluated serum concentrations of tumor necrosis factor α, interleukins 4 and 8, monocyte chemotactic protein-1 (MCP-1), vascular endothelial growth factor, and epidermal growth factor (EGF) before and at 4 and 8 weeks after surgery. We also determined the Radiographic Union Score for Hips and the Radius Union Scoring System score and applied the Physical Activity Scale for the Elderly test at the same time points. Each patient underwent bone densitometry.
Results
MCP-1 and EGF levels were higher in group A than in group B at 4 weeks after surgery (
p
> 0.05). Radiographic evaluation showed lower scores in group A (
p
|
| doi_str_mv | 10.1007/s40520-015-0422-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1715658370</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1715658370</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-751144865f2f2a2bef26d892815d53cc741d0364100709b5ea73fa61dc060b7b3</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0Eou3CB-gFWeLCJeBx7DjhhipoK1XiAmfLsSdbl_yrJ0Fa9cvj7Za2QuLksef3nkfzGDsF8RGEMJ9ICS1FIUAXQklZqBfsGEx-qUtoXj6rj9gJ0Y0QCvLlNTuSFTTGQH3M7i6H2cWEgV-j6-O45VPHu-S2sY_Lbl_5ZU1IPI582c3IJQ_RtbggfeY-C6J3PXdj4MmFOG2Tm6-j544IiQYcF7pvEqZ14H63TL_iiLzH39jTG_aqcz3h24dzw35--_rj7KK4-n5-efblqvClkUthNIBSdaU72UknW-xkFepG1qCDLr03CoIoK7VfiWhajc6UnasgeFGJ1rTlhn04-M5pul2RFjtE8tj3bsRpJQsGdKXr0oiMvv8HvZnWNObprCxVA6DrvMMNgwPl00SUsLNzioNLOwvC7sewh2RsTsbuk7Eqa949OK_tgOFR8TeKDMgDQLk1bjE9ff1_1z_qfJju</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2349115841</pqid></control><display><type>article</type><title>Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Liuni, Federico Maria ; Rugiero, Clelia ; Feola, Maurizio ; Rao, Cecilia ; Pistillo, Pietro ; Terracciano, Chiara ; Giganti, Maria Gabriella ; Tarantino, Umberto</creator><creatorcontrib>Liuni, Federico Maria ; Rugiero, Clelia ; Feola, Maurizio ; Rao, Cecilia ; Pistillo, Pietro ; Terracciano, Chiara ; Giganti, Maria Gabriella ; Tarantino, Umberto</creatorcontrib><description>Background
Diabetes induces bone alterations accompanied by altered cytokine expression patterns. These alterations lead to modified fracture healing, contributing to musculoskeletal fragility in the elderly.
Aims
We evaluated the inflammatory immune response in diabetic patients during fracture healing relative to clinical and radiographic assessments.
Methods
Fifty patients of both sexes with fragility fractures were studied: 30 diabetics (group A, mean age 73.4 ± 11.2 years) and 20 normoglycemic controls (group B, mean age 75.1 ± 16.9 years). Two subgroups comprised those with hip or wrist fragility fractures (25 and 16 patients, respectively). We evaluated serum concentrations of tumor necrosis factor α, interleukins 4 and 8, monocyte chemotactic protein-1 (MCP-1), vascular endothelial growth factor, and epidermal growth factor (EGF) before and at 4 and 8 weeks after surgery. We also determined the Radiographic Union Score for Hips and the Radius Union Scoring System score and applied the Physical Activity Scale for the Elderly test at the same time points. Each patient underwent bone densitometry.
Results
MCP-1 and EGF levels were higher in group A than in group B at 4 weeks after surgery (
p
> 0.05). Radiographic evaluation showed lower scores in group A (
p
< 0.05). The main difference between the groups was evident 4 weeks after surgery. Changes in the serum concentrations of chemotactic and angiogenic factors could explain the radiographically proved impaired fracture healing in diabetic patients.
Conclusions
Fragility fracture healing is impaired in diabetic patients. Radiographic and molecular patterns confirmed that the most compromised fracture-healing phase is at 4 weeks after surgery, during callus mineralization.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-015-0422-4</identifier><identifier>PMID: 26197718</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Aged, 80 and over ; Chemokine CCL2 - blood ; Cytokines ; Cytokines - blood ; Densitometry - methods ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - immunology ; Epidermal growth factor ; Female ; Fracture Fixation - adverse effects ; Fracture Fixation - methods ; Fracture Healing - immunology ; Fractures ; Geriatrics/Gerontology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Osteoporotic Fractures - diagnostic imaging ; Osteoporotic Fractures - immunology ; Postoperative Period ; Radiography ; Radius Fractures - diagnostic imaging ; Radius Fractures - etiology ; Radius Fractures - surgery ; Surgery ; Tumor Necrosis Factor-alpha - blood ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Aging clinical and experimental research, 2015-10, Vol.27 (Suppl 1), p.37-44</ispartof><rights>Springer International Publishing Switzerland 2015</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2015). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-751144865f2f2a2bef26d892815d53cc741d0364100709b5ea73fa61dc060b7b3</citedby><cites>FETCH-LOGICAL-c372t-751144865f2f2a2bef26d892815d53cc741d0364100709b5ea73fa61dc060b7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-015-0422-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-015-0422-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26197718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liuni, Federico Maria</creatorcontrib><creatorcontrib>Rugiero, Clelia</creatorcontrib><creatorcontrib>Feola, Maurizio</creatorcontrib><creatorcontrib>Rao, Cecilia</creatorcontrib><creatorcontrib>Pistillo, Pietro</creatorcontrib><creatorcontrib>Terracciano, Chiara</creatorcontrib><creatorcontrib>Giganti, Maria Gabriella</creatorcontrib><creatorcontrib>Tarantino, Umberto</creatorcontrib><title>Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Diabetes induces bone alterations accompanied by altered cytokine expression patterns. These alterations lead to modified fracture healing, contributing to musculoskeletal fragility in the elderly.
Aims
We evaluated the inflammatory immune response in diabetic patients during fracture healing relative to clinical and radiographic assessments.
Methods
Fifty patients of both sexes with fragility fractures were studied: 30 diabetics (group A, mean age 73.4 ± 11.2 years) and 20 normoglycemic controls (group B, mean age 75.1 ± 16.9 years). Two subgroups comprised those with hip or wrist fragility fractures (25 and 16 patients, respectively). We evaluated serum concentrations of tumor necrosis factor α, interleukins 4 and 8, monocyte chemotactic protein-1 (MCP-1), vascular endothelial growth factor, and epidermal growth factor (EGF) before and at 4 and 8 weeks after surgery. We also determined the Radiographic Union Score for Hips and the Radius Union Scoring System score and applied the Physical Activity Scale for the Elderly test at the same time points. Each patient underwent bone densitometry.
Results
MCP-1 and EGF levels were higher in group A than in group B at 4 weeks after surgery (
p
> 0.05). Radiographic evaluation showed lower scores in group A (
p
< 0.05). The main difference between the groups was evident 4 weeks after surgery. Changes in the serum concentrations of chemotactic and angiogenic factors could explain the radiographically proved impaired fracture healing in diabetic patients.
Conclusions
Fragility fracture healing is impaired in diabetic patients. Radiographic and molecular patterns confirmed that the most compromised fracture-healing phase is at 4 weeks after surgery, during callus mineralization.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chemokine CCL2 - blood</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Densitometry - methods</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Epidermal growth factor</subject><subject>Female</subject><subject>Fracture Fixation - adverse effects</subject><subject>Fracture Fixation - methods</subject><subject>Fracture Healing - immunology</subject><subject>Fractures</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Osteoporotic Fractures - diagnostic imaging</subject><subject>Osteoporotic Fractures - immunology</subject><subject>Postoperative Period</subject><subject>Radiography</subject><subject>Radius Fractures - diagnostic imaging</subject><subject>Radius Fractures - etiology</subject><subject>Radius Fractures - surgery</subject><subject>Surgery</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU9v1DAQxS0Eou3CB-gFWeLCJeBx7DjhhipoK1XiAmfLsSdbl_yrJ0Fa9cvj7Za2QuLksef3nkfzGDsF8RGEMJ9ICS1FIUAXQklZqBfsGEx-qUtoXj6rj9gJ0Y0QCvLlNTuSFTTGQH3M7i6H2cWEgV-j6-O45VPHu-S2sY_Lbl_5ZU1IPI582c3IJQ_RtbggfeY-C6J3PXdj4MmFOG2Tm6-j544IiQYcF7pvEqZ14H63TL_iiLzH39jTG_aqcz3h24dzw35--_rj7KK4-n5-efblqvClkUthNIBSdaU72UknW-xkFepG1qCDLr03CoIoK7VfiWhajc6UnasgeFGJ1rTlhn04-M5pul2RFjtE8tj3bsRpJQsGdKXr0oiMvv8HvZnWNObprCxVA6DrvMMNgwPl00SUsLNzioNLOwvC7sewh2RsTsbuk7Eqa949OK_tgOFR8TeKDMgDQLk1bjE9ff1_1z_qfJju</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Liuni, Federico Maria</creator><creator>Rugiero, Clelia</creator><creator>Feola, Maurizio</creator><creator>Rao, Cecilia</creator><creator>Pistillo, Pietro</creator><creator>Terracciano, Chiara</creator><creator>Giganti, Maria Gabriella</creator><creator>Tarantino, Umberto</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels</title><author>Liuni, Federico Maria ; Rugiero, Clelia ; Feola, Maurizio ; Rao, Cecilia ; Pistillo, Pietro ; Terracciano, Chiara ; Giganti, Maria Gabriella ; Tarantino, Umberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-751144865f2f2a2bef26d892815d53cc741d0364100709b5ea73fa61dc060b7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chemokine CCL2 - blood</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Densitometry - methods</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Epidermal growth factor</topic><topic>Female</topic><topic>Fracture Fixation - adverse effects</topic><topic>Fracture Fixation - methods</topic><topic>Fracture Healing - immunology</topic><topic>Fractures</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Osteoporotic Fractures - diagnostic imaging</topic><topic>Osteoporotic Fractures - immunology</topic><topic>Postoperative Period</topic><topic>Radiography</topic><topic>Radius Fractures - diagnostic imaging</topic><topic>Radius Fractures - etiology</topic><topic>Radius Fractures - surgery</topic><topic>Surgery</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liuni, Federico Maria</creatorcontrib><creatorcontrib>Rugiero, Clelia</creatorcontrib><creatorcontrib>Feola, Maurizio</creatorcontrib><creatorcontrib>Rao, Cecilia</creatorcontrib><creatorcontrib>Pistillo, Pietro</creatorcontrib><creatorcontrib>Terracciano, Chiara</creatorcontrib><creatorcontrib>Giganti, Maria Gabriella</creatorcontrib><creatorcontrib>Tarantino, Umberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liuni, Federico Maria</au><au>Rugiero, Clelia</au><au>Feola, Maurizio</au><au>Rao, Cecilia</au><au>Pistillo, Pietro</au><au>Terracciano, Chiara</au><au>Giganti, Maria Gabriella</au><au>Tarantino, Umberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>27</volume><issue>Suppl 1</issue><spage>37</spage><epage>44</epage><pages>37-44</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Diabetes induces bone alterations accompanied by altered cytokine expression patterns. These alterations lead to modified fracture healing, contributing to musculoskeletal fragility in the elderly.
Aims
We evaluated the inflammatory immune response in diabetic patients during fracture healing relative to clinical and radiographic assessments.
Methods
Fifty patients of both sexes with fragility fractures were studied: 30 diabetics (group A, mean age 73.4 ± 11.2 years) and 20 normoglycemic controls (group B, mean age 75.1 ± 16.9 years). Two subgroups comprised those with hip or wrist fragility fractures (25 and 16 patients, respectively). We evaluated serum concentrations of tumor necrosis factor α, interleukins 4 and 8, monocyte chemotactic protein-1 (MCP-1), vascular endothelial growth factor, and epidermal growth factor (EGF) before and at 4 and 8 weeks after surgery. We also determined the Radiographic Union Score for Hips and the Radius Union Scoring System score and applied the Physical Activity Scale for the Elderly test at the same time points. Each patient underwent bone densitometry.
Results
MCP-1 and EGF levels were higher in group A than in group B at 4 weeks after surgery (
p
> 0.05). Radiographic evaluation showed lower scores in group A (
p
< 0.05). The main difference between the groups was evident 4 weeks after surgery. Changes in the serum concentrations of chemotactic and angiogenic factors could explain the radiographically proved impaired fracture healing in diabetic patients.
Conclusions
Fragility fracture healing is impaired in diabetic patients. Radiographic and molecular patterns confirmed that the most compromised fracture-healing phase is at 4 weeks after surgery, during callus mineralization.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>26197718</pmid><doi>10.1007/s40520-015-0422-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8319 |
| ispartof | Aging clinical and experimental research, 2015-10, Vol.27 (Suppl 1), p.37-44 |
| issn | 1720-8319 1594-0667 1720-8319 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1715658370 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Aged, 80 and over Chemokine CCL2 - blood Cytokines Cytokines - blood Densitometry - methods Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology Epidermal growth factor Female Fracture Fixation - adverse effects Fracture Fixation - methods Fracture Healing - immunology Fractures Geriatrics/Gerontology Humans Male Medicine Medicine & Public Health Middle Aged Original Article Osteoporotic Fractures - diagnostic imaging Osteoporotic Fractures - immunology Postoperative Period Radiography Radius Fractures - diagnostic imaging Radius Fractures - etiology Radius Fractures - surgery Surgery Tumor Necrosis Factor-alpha - blood Vascular Endothelial Growth Factor A - blood |
| title | Impaired healing of fragility fractures in type 2 diabetes: clinical and radiographic assessments and serum cytokine levels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T21%3A42%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impaired%20healing%20of%20fragility%20fractures%20in%20type%202%20diabetes:%20clinical%20and%20radiographic%20assessments%20and%20serum%20cytokine%20levels&rft.jtitle=Aging%20clinical%20and%20experimental%20research&rft.au=Liuni,%20Federico%20Maria&rft.date=2015-10-01&rft.volume=27&rft.issue=Suppl%201&rft.spage=37&rft.epage=44&rft.pages=37-44&rft.issn=1720-8319&rft.eissn=1720-8319&rft_id=info:doi/10.1007/s40520-015-0422-4&rft_dat=%3Cproquest_cross%3E1715658370%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2349115841&rft_id=info:pmid/26197718&rfr_iscdi=true |