ROLE OF HEPATIC FATTY ACID:COENZYME A LIGASES IN THE METABOLISM OF XENOBIOTIC CARBOXYLIC ACIDS

SUMMARY 1. Formation of acyl‐coenzymes (Co)A occurs as an obligatory step in the metabolism of a variety of endogenous substrates, including fatty acids. The reaction is catalysed by ATP‐dependent acid:CoA ligases (EC 6.2.1.1‐2.1.3; AMP forming), classified on the basis of their ability to conjugate...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1998-10, Vol.25 (10), p.776-782
1. Verfasser:	Knights, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetate-CoA Ligase - genetics Acetate-CoA Ligase - metabolism Animals arylpropionyl-coenzyme A thioesters Carboxylic Acids - metabolism coenzyme A Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism drug metabolism Humans Liver - enzymology long-chain-fatty acid-coenzyme A-ligase Repressor Proteins Saccharomyces cerevisiae Proteins Substrate Specificity xenobiotic carboxylic acids xenobiotic-coenzyme A thioesters Xenobiotics - metabolism Xenobiotics - toxicity
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