Effect of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine as evaluated by step-through avoidance response in rats

In the present study, the effects of endogenous histamine in the ventral hippocampus on fear memory deficits induced by scopolamine were investigated as evaluated by step-through avoidance response in adult male rats. Bilateral ventral hippocampal injection of scopolamine (i.h., 2, 5 μg/site) signif...

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Veröffentlicht in:	Physiology & behavior 2006-04, Vol.87 (4), p.687-693
Hauptverfasser:	Yu, Chaoyang, Shen, Yao, Xu, Lisha, Zhu, Yuanyuan, Zhuge, Zhenbin, Huang, Yuwen, Henk, Timmerman, Rob, Leurs, Wei, Erqing, Chen, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Active avoidance response Animals Avoidance Learning - drug effects Avoidance Learning - physiology Behavioral psychophysiology Biological and medical sciences Clobenpropit Dose-Response Relationship, Drug Fear - drug effects Fear - physiology Fear memory Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Histamine Histamine - metabolism Histamine Agonists - administration & dosage Histamine Antagonists - administration & dosage Hormones and behavior Male Memory - drug effects Memory - physiology Memory Disorders - chemically induced Microinjections Motor Activity - drug effects Motor Activity - physiology Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Reaction Time - drug effects Reaction Time - physiology Scopolamine Scopolamine Hydrobromide α-Fluoromethylhistidine
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