Cyanide Detoxification by the Cobalamin Precursor Cobinamide

Cyanide is a highly toxic agent that inhibits mitochondrial cytochrome-c oxidase, thereby depleting cellular ATP. it contributes to smoke inhalation deaths in fires and could be used as a weapon of mass destruction. Cobalamin (vitamin B12) binds cyanide with a relatively high affinity and is used in...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2006-05, Vol.231 (5), p.641-649
Hauptverfasser:	Broderick, Kate E., Potluri, Prasanth, Zhuang, Shunhui, Scheffler, Immo E., Sharma, Vijay S., Pilz, Renate B., Boss, Gerry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CHO Cells Cobamides - chemistry Cobamides - pharmacokinetics Cobamides - therapeutic use Cricetinae Cyanides - administration & dosage Cyanides - metabolism Cyanides - toxicity Drosophila melanogaster Humans Inactivation, Metabolic Molecular Structure Smoke Inhalation Injury - drug therapy Vitamin B 12 - chemistry Vitamin B 12 - metabolism Vitamin B 12 - therapeutic use Vitamin B Complex - metabolism
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