1-Trichloromethyl-1,2,3,4-tetrahydro- β-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats

1-Trichloromethyl-1,2,3,4-tetrahydro- β-carboline (TaClo), a neurotoxin structurally similar to the dopaminergic neurotoxin MPTP, may be formed in humans treated with chloral hydrate or exposed to trichloroethylene, a widely used industrial solvent. Systemically administered TaClo (0.4 mg/kg, i.p.)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 1998-11, Vol.257 (1), p.17-20
Hauptverfasser:	Gerlach, Manfred, Xiao, Ai-Ying, Heim, Christine, Lan, Jing, God, Ralf, Feineis, Doris, Bringmann, Gerhard, Riederer, Peter, Sontag, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Trichloromethyl-1,2,3,4-tetrahydro- β-carboline 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Aspartic Acid - metabolism Biological and medical sciences Carbolines - pharmacology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Dopamine - metabolism Extracellular Space - metabolism Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Homovanillic Acid - metabolism Hydroxybenzoates - metabolism Hydroxyindoleacetic Acid - metabolism Hydroxyl Radical - metabolism Hydroxyl radicals Male Microdialysis Neurotoxins Parkinson's disease Rats Rats, Wistar Serotonin Serotonin - metabolism Vertebrates: nervous system and sense organs β-Carbolines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!