Dexamethasone prevents the induction of COX-2 mRNA and prostaglandins in the lumbar spinal cord following intraplantar FCA in parallel with inhibition of oedema

The inducible form of cyclo-oxygenase (COX-2) mRNA is rapidly induced in the spinal cord following peripheral inflammation produced by intraplantar injection of Freund’s complete adjuvant (FCA). COX-2 mRNA induction is also accompanied by increased prostaglandin (PG) levels which are closely correla...

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Veröffentlicht in:	Neuropharmacology 1998-06, Vol.37 (6), p.739-744
Hauptverfasser:	Hay, C.H, de Belleroche, J.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclo-oxygenase-2 Cyclooxygenase 2 Dexamethasone Dexamethasone - pharmacology Dexamethasone - therapeutic use Edema - chemically induced Edema - prevention & control Freund's Adjuvant Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Inflammation Injections, Spinal Isoenzymes - biosynthesis Male Medical sciences mRNA Oedema Pharmacology. Drug treatments Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandins Prostaglandins - biosynthesis Rats RNA, Messenger - metabolism Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord Diseases - chemically induced Spinal Cord Diseases - prevention & control
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