Determination of Apurinic/Apyrimidinic Lesions in DNA with High-Performance Liquid Chromatography and Tandem Mass Spectrometry

A new method has been developed to accurately measure apurinic and apyrimidinic (AP) DNA damage sites, which are lesions in DNA formed by loss of a nucleobase from oxidative stress or carcinogen adducts. If AP sites are left unrepaired (or if improperly repaired), these sites can lead to DNA mutatio...

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Veröffentlicht in:	Chemical research in toxicology 2006-02, Vol.19 (2), p.300-309
Hauptverfasser:	Roberts, Kenneth P, Sobrino, Justin A, Payton, Julie, Mason, Lavinnia B, Turesky, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Chromatography, High Pressure Liquid - methods DNA - analysis DNA Damage Hydroxylamines - chemical synthesis Hydroxylamines - chemistry Molecular Structure Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Staining and Labeling Time Factors
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