Sex- and strain-specific expression of cytochrome P450s in Ochratoxin A-induced genotoxicity and carcinogenicity in rats

Ochratoxin A (OTA), a nephrotoxic and carcinogenic mycotoxin, is implicated in the etiology of Balkan endemic nephropathy (BEN), a chronic disease affecting populations in the Balkans. Patients suffering from Balkan endemic nephropathy, urinary‐tract tumors, or both are more frequently extensive met...

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Veröffentlicht in:	Molecular carcinogenesis 1998-10, Vol.23 (2), p.76-85
Hauptverfasser:	Pfohl-Leszkowicz, Annie, Pinelli, Eric, Bartsch, Helmut, Mohr, Ulrich, Castegnaro, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carcinogenicity Carcinogens - toxicity Cytochrome P-450 Enzyme System - metabolism cytochrome P450 DNA adducts DNA Adducts - metabolism Female genotoxicity Isoenzymes - metabolism Kidney - drug effects Kidney - enzymology Kidney - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Male Microsomes - drug effects Microsomes - enzymology Microsomes - metabolism Mutagens - toxicity Ochratoxin A Ochratoxins - toxicity polymorphism Rats Rats, Inbred Lew Species Specificity
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