Pregnenolone sulfate modulates NMDA receptors, inducing and potentiating acute excitotoxicity in isolated retina

Pregnenolone sulfate (PS) acts as a positive allosteric modulator of N‐methyl‐D‐aspartate (NMDA) receptor‐mediated responses. In the retina, we previously observed that the synthesis of pregnenolone and PS increases after stimulation of NMDA receptors and blockade of the synthesis reduces retinal ce...

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Veröffentlicht in:	Journal of neuroscience research 1998-12, Vol.54 (6), p.787-797
Hauptverfasser:	Guarneri, P., Russo, D., Cascio, C., De Leo, G., Piccoli, T., Sciuto, V., Piccoli, F., Guarneri, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute excitotoxicity Animals Dizocilpine Maleate - metabolism Drug Synergism L-Lactate Dehydrogenase - metabolism Male N-Methylaspartate - toxicity Neuroprotective Agents - metabolism Neurotoxins - toxicity NMDA receptors Pregnenolone - toxicity pregnenolone sulfate Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism retina Retina - drug effects Retina - metabolism
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