Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus

The hyaluronic acid capsule of group A Streptococcus (GAS) is an important virulence factor, but little is known about mechanisms that regulate capsule expression. Transposon Tn916 mutagenesis of the poorly encapsulated M‐type 3 GAS strain DLS003 produced a transconjugant that exhibited a mucoid col...

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Veröffentlicht in:	Molecular microbiology 1998-10, Vol.30 (1), p.209-219
Hauptverfasser:	Levin, James C., Wessels, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bacterial Capsules - biosynthesis Base Sequence Gene Deletion Gene Expression Regulation, Bacterial Genes, Bacterial Humans Hyaluronic Acid - biosynthesis Male Mice Mice, Inbred ICR Mutagenesis, Insertional Open Reading Frames Phagocytosis Plasmids - genetics Streptococcus Streptococcus pyogenes - genetics Streptococcus pyogenes - metabolism Streptococcus pyogenes - pathogenicity Transcription, Genetic Virulence - genetics
Online-Zugang:	Volltext
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