The Impact of c‐Fos/Activator Protein‐1 Inhibition on Allogeneic Pancreatic Islet Transplantation

Unpreventable allograft rejection is one of the main problems in pancreatic islet transplantation (PIT). Therefore, it is imperative to develop a more effective immunosuppressive strategy. The blockade of transcription factors has been a central part of T cell–depleting immunosuppressive therapies,...

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Veröffentlicht in:	American journal of transplantation 2015-10, Vol.15 (10), p.2565-2575
Hauptverfasser:	Yoshida, T., Yamashita, K., Watanabe, M., Koshizuka, Y., Kuraya, D., Ogura, M., Asahi, Y., Ono, H., Emoto, S., Mizukami, T., Kobayashi, N., Shibasaki, S., Tomaru, U., Kamachi, H., Matsushita, M., Shiozawa, S., Hirono, S., Todo, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Basic (laboratory) research/science Benzophenones - pharmacology Benzophenones - therapeutic use Calcineurin Calcineurin inhibitors CD25 antigen Cell proliferation Graft rejection Graft Rejection - immunology Graft Rejection - prevention & control Immunosuppression Immunosuppressive agents Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Interferon Islet cells Islets of Langerhans Transplantation - immunology Isoxazoles - pharmacology Isoxazoles - therapeutic use Lymphocytes T Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Nuclear transport Pancreas Pancreas transplantation Pancreatic islet transplantation Proteins Proto-Oncogene Proteins c-fos - antagonists & inhibitors Rodents T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Tacrolimus Transcription Factor AP-1 - antagonists & inhibitors Transcription factors Transplantation, Homologous Transplants & implants
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