Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation

An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)3 or Pd/C. The catalyst Pd/C could be easily removed from th...

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Veröffentlicht in:Organic letters 2015-09, Vol.17 (18), p.4526-4529
Hauptverfasser: Xu, Tongyu, Alper, Howard
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container_title Organic letters
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creator Xu, Tongyu
Alper, Howard
description An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)3 or Pd/C. The catalyst Pd/C could be easily removed from the reaction and recycled.
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title Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation
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