Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production
We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopatholog...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric hematology/oncology 2015-10, Vol.37 (7), p.554-559 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 559 |
|---|---|
| container_issue | 7 |
| container_start_page | 554 |
| container_title | Journal of pediatric hematology/oncology |
| container_volume | 37 |
| creator | Akiyama, Masaharu Yamaoka, Masayoshi Mikami-Terao, Yoko Yokoi, Kentaro Inoue, Takashi Hiramatsu, Tomomasa Ashizuka, Shuichi Yoshizawa, Jyoji Katagi, Hiroaki Ikegami, Masahiro Ida, Hiroyuki Nakazawa, Atsuko Okita, Hajime Matsumoto, Kenji |
| description | We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH. |
| doi_str_mv | 10.1097/MPH.0000000000000390 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1713942943</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1713942943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-cc435972deca38e53145803674c5c33a02e220808fe7af9417f9a11d1c040073</originalsourceid><addsrcrecordid>eNpdUV1L7DAQDaKoV_0HInn0pTrTpE37qMuuKyguKvhYsun0kmvbrEkr9i_4q2_EDy53XmbgnDPDnMPYMcIZQqnOb1fLM_i3RAlbbB8zkSciV8V2nEGpRCLKPfYrhD8AqIRMd9lemmOeSRD77H2lve7JbVodBmv4w9TX3nXEXcMv-t_WdXpwtuYLu_ZuDHxpI82ZaYgAv9UTvyQ-02Ogmq8nPn96uMdkdj-_RL4Yg3V9Yvt6NBGdvxkKwb4Sv-4H8i2Nz7ZPcr7yLhLizv6Q7TS6DXT01Q_Y42L-OFsmN3dX17OLm8QIUENijBRZqdKajBYFZQJlVkD8WJrMCKEhpTSFAoqGlG5KiaopNWKNBiSAEgfs9HPtxruXkcJQdTYYatsPG8ZQoUJRyrSUIlLlJ9V4F4Knptp422k_VQjVRwhVDKH6P4QoO_m6MK47qn9E366Lvx0Dgfk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1713942943</pqid></control><display><type>article</type><title>Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Akiyama, Masaharu ; Yamaoka, Masayoshi ; Mikami-Terao, Yoko ; Yokoi, Kentaro ; Inoue, Takashi ; Hiramatsu, Tomomasa ; Ashizuka, Shuichi ; Yoshizawa, Jyoji ; Katagi, Hiroaki ; Ikegami, Masahiro ; Ida, Hiroyuki ; Nakazawa, Atsuko ; Okita, Hajime ; Matsumoto, Kenji</creator><creatorcontrib>Akiyama, Masaharu ; Yamaoka, Masayoshi ; Mikami-Terao, Yoko ; Yokoi, Kentaro ; Inoue, Takashi ; Hiramatsu, Tomomasa ; Ashizuka, Shuichi ; Yoshizawa, Jyoji ; Katagi, Hiroaki ; Ikegami, Masahiro ; Ida, Hiroyuki ; Nakazawa, Atsuko ; Okita, Hajime ; Matsumoto, Kenji</creatorcontrib><description>We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/MPH.0000000000000390</identifier><identifier>PMID: 26165403</identifier><language>eng</language><publisher>United States</publisher><subject>Child ; Female ; Histiocytoma, Malignant Fibrous - complications ; Histiocytoma, Malignant Fibrous - genetics ; Histiocytoma, Malignant Fibrous - pathology ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Interleukin-6 - biosynthesis ; Interleukin-6 - genetics ; Oncogene Proteins, Fusion - genetics ; Paraneoplastic Syndromes - etiology ; Reverse Transcriptase Polymerase Chain Reaction ; Soft Tissue Neoplasms - complications ; Soft Tissue Neoplasms - genetics ; Soft Tissue Neoplasms - pathology</subject><ispartof>Journal of pediatric hematology/oncology, 2015-10, Vol.37 (7), p.554-559</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-cc435972deca38e53145803674c5c33a02e220808fe7af9417f9a11d1c040073</citedby><cites>FETCH-LOGICAL-c307t-cc435972deca38e53145803674c5c33a02e220808fe7af9417f9a11d1c040073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26165403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akiyama, Masaharu</creatorcontrib><creatorcontrib>Yamaoka, Masayoshi</creatorcontrib><creatorcontrib>Mikami-Terao, Yoko</creatorcontrib><creatorcontrib>Yokoi, Kentaro</creatorcontrib><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Hiramatsu, Tomomasa</creatorcontrib><creatorcontrib>Ashizuka, Shuichi</creatorcontrib><creatorcontrib>Yoshizawa, Jyoji</creatorcontrib><creatorcontrib>Katagi, Hiroaki</creatorcontrib><creatorcontrib>Ikegami, Masahiro</creatorcontrib><creatorcontrib>Ida, Hiroyuki</creatorcontrib><creatorcontrib>Nakazawa, Atsuko</creatorcontrib><creatorcontrib>Okita, Hajime</creatorcontrib><creatorcontrib>Matsumoto, Kenji</creatorcontrib><title>Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.</description><subject>Child</subject><subject>Female</subject><subject>Histiocytoma, Malignant Fibrous - complications</subject><subject>Histiocytoma, Malignant Fibrous - genetics</subject><subject>Histiocytoma, Malignant Fibrous - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-6 - genetics</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Paraneoplastic Syndromes - etiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Soft Tissue Neoplasms - complications</subject><subject>Soft Tissue Neoplasms - genetics</subject><subject>Soft Tissue Neoplasms - pathology</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUV1L7DAQDaKoV_0HInn0pTrTpE37qMuuKyguKvhYsun0kmvbrEkr9i_4q2_EDy53XmbgnDPDnMPYMcIZQqnOb1fLM_i3RAlbbB8zkSciV8V2nEGpRCLKPfYrhD8AqIRMd9lemmOeSRD77H2lve7JbVodBmv4w9TX3nXEXcMv-t_WdXpwtuYLu_ZuDHxpI82ZaYgAv9UTvyQ-02Ogmq8nPn96uMdkdj-_RL4Yg3V9Yvt6NBGdvxkKwb4Sv-4H8i2Nz7ZPcr7yLhLizv6Q7TS6DXT01Q_Y42L-OFsmN3dX17OLm8QIUENijBRZqdKajBYFZQJlVkD8WJrMCKEhpTSFAoqGlG5KiaopNWKNBiSAEgfs9HPtxruXkcJQdTYYatsPG8ZQoUJRyrSUIlLlJ9V4F4Knptp422k_VQjVRwhVDKH6P4QoO_m6MK47qn9E366Lvx0Dgfk</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Akiyama, Masaharu</creator><creator>Yamaoka, Masayoshi</creator><creator>Mikami-Terao, Yoko</creator><creator>Yokoi, Kentaro</creator><creator>Inoue, Takashi</creator><creator>Hiramatsu, Tomomasa</creator><creator>Ashizuka, Shuichi</creator><creator>Yoshizawa, Jyoji</creator><creator>Katagi, Hiroaki</creator><creator>Ikegami, Masahiro</creator><creator>Ida, Hiroyuki</creator><creator>Nakazawa, Atsuko</creator><creator>Okita, Hajime</creator><creator>Matsumoto, Kenji</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production</title><author>Akiyama, Masaharu ; Yamaoka, Masayoshi ; Mikami-Terao, Yoko ; Yokoi, Kentaro ; Inoue, Takashi ; Hiramatsu, Tomomasa ; Ashizuka, Shuichi ; Yoshizawa, Jyoji ; Katagi, Hiroaki ; Ikegami, Masahiro ; Ida, Hiroyuki ; Nakazawa, Atsuko ; Okita, Hajime ; Matsumoto, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-cc435972deca38e53145803674c5c33a02e220808fe7af9417f9a11d1c040073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Child</topic><topic>Female</topic><topic>Histiocytoma, Malignant Fibrous - complications</topic><topic>Histiocytoma, Malignant Fibrous - genetics</topic><topic>Histiocytoma, Malignant Fibrous - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-6 - genetics</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Paraneoplastic Syndromes - etiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Soft Tissue Neoplasms - complications</topic><topic>Soft Tissue Neoplasms - genetics</topic><topic>Soft Tissue Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akiyama, Masaharu</creatorcontrib><creatorcontrib>Yamaoka, Masayoshi</creatorcontrib><creatorcontrib>Mikami-Terao, Yoko</creatorcontrib><creatorcontrib>Yokoi, Kentaro</creatorcontrib><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Hiramatsu, Tomomasa</creatorcontrib><creatorcontrib>Ashizuka, Shuichi</creatorcontrib><creatorcontrib>Yoshizawa, Jyoji</creatorcontrib><creatorcontrib>Katagi, Hiroaki</creatorcontrib><creatorcontrib>Ikegami, Masahiro</creatorcontrib><creatorcontrib>Ida, Hiroyuki</creatorcontrib><creatorcontrib>Nakazawa, Atsuko</creatorcontrib><creatorcontrib>Okita, Hajime</creatorcontrib><creatorcontrib>Matsumoto, Kenji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akiyama, Masaharu</au><au>Yamaoka, Masayoshi</au><au>Mikami-Terao, Yoko</au><au>Yokoi, Kentaro</au><au>Inoue, Takashi</au><au>Hiramatsu, Tomomasa</au><au>Ashizuka, Shuichi</au><au>Yoshizawa, Jyoji</au><au>Katagi, Hiroaki</au><au>Ikegami, Masahiro</au><au>Ida, Hiroyuki</au><au>Nakazawa, Atsuko</au><au>Okita, Hajime</au><au>Matsumoto, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2015-10</date><risdate>2015</risdate><volume>37</volume><issue>7</issue><spage>554</spage><epage>559</epage><pages>554-559</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><abstract>We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.</abstract><cop>United States</cop><pmid>26165403</pmid><doi>10.1097/MPH.0000000000000390</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2015-10, Vol.37 (7), p.554-559 |
| issn | 1077-4114 1536-3678 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1713942943 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Child Female Histiocytoma, Malignant Fibrous - complications Histiocytoma, Malignant Fibrous - genetics Histiocytoma, Malignant Fibrous - pathology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Interleukin-6 - biosynthesis Interleukin-6 - genetics Oncogene Proteins, Fusion - genetics Paraneoplastic Syndromes - etiology Reverse Transcriptase Polymerase Chain Reaction Soft Tissue Neoplasms - complications Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology |
| title | Paraneoplastic Syndrome of Angiomatoid Fibrous Histiocytoma May Be Caused by EWSR1-CREB1 Fusion-induced Excessive Interleukin-6 Production |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T04%3A39%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paraneoplastic%20Syndrome%20of%20Angiomatoid%20Fibrous%20Histiocytoma%20May%20Be%20Caused%20by%20EWSR1-CREB1%20Fusion-induced%20Excessive%20Interleukin-6%20Production&rft.jtitle=Journal%20of%20pediatric%20hematology/oncology&rft.au=Akiyama,%20Masaharu&rft.date=2015-10&rft.volume=37&rft.issue=7&rft.spage=554&rft.epage=559&rft.pages=554-559&rft.issn=1077-4114&rft.eissn=1536-3678&rft_id=info:doi/10.1097/MPH.0000000000000390&rft_dat=%3Cproquest_cross%3E1713942943%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1713942943&rft_id=info:pmid/26165403&rfr_iscdi=true |